Wuhan Ll Science and Technology Development Co., Ltd.

Wuhan Humanwell Innovative Drug Research and Development Center Limited Company

Xiaohua Ding

Zhe Liu

Lie Li

Xuejun Zhang

Chaodong Wang

Yongkai Chen

Bo Zhang

Jie Shen

Sijun Lei

Xueming Liu

Panpan Duan

Dongcheng Dai

Yang Zang

Hongna Sun

Dabing Ye

Yonggang Wei

Provided is a new compound capable of effectively inhibiting ATX. The compound is represented by formula I, or the compound is a tautomer, a stereoisomer, a hydrate, a solvate, a salt, or a prodrug of the compound represented by formula I. In formula (I), Rand Rare independently selected from —H or —CH, provided that: Rand Rare not —H at the same time or are not —CHat the same time.

Pyrrolopyrimidine derivative and use thereof

The present disclosure belongs to the field of chemical synthesis, and in particular relates to an ammonium carboxylate compound, a crystalline form and an amorphous form, and a preparation method thereof. The present disclosure prepares the compound and the crystalline form I and its single crystal, amorphous form and crystalline form II thereof. The compound, the crystalline forms, the single crystal and the amorphous form can stably exist and exhibit good solid forms, suitable for medicine-making. Furthermore, these products possess high purity and less single impurity. Moreover, the preparation methods of the present disclosure are easy to implement due to the simple processes with mild reaction conditions, and could produce products of high yield and high purity without complex purification steps. Furthermore, the preparation methods may facilitate safety, environmental protection, and industrial production.

Ammonium carboxylate compound, crystalline form, amorphous form and preparation method thereof

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Hubei, China

Xiaohua Ding