Merck Sharp + Dohme Corp.

Schering Corporation

Other

Schering-plough Corporation

Xiaohong Zhu

Robert G Aslanian

William J Greenlee

Xianhai Huang

Zhaoning Zhu

Anandan Palani

Kevin D McCormick

Michael Berlin

Manuel De Lera Ruiz

Wei Zhou

Jun Qin

Christopher W Boyce

Daniel M Solomon

Wing C Tom

Zhong-Yue Sun

Junying Zheng

Henry A Vaccaro

Mwangi W Mutahi

Gioconda V Gallo

Neng-Yang Shih

John W Clader

Hubert B Josien

Stuart B Rosenblum

Purakkattle J Biju

Robert D Mazzola, Jr

Dmitri A Pissarnitski

Hongmei Li

Pietro Mangiaracina

Jianhua Chao

Zhiqiang Zhao

Ruo Xu

Chad E Bennett

Mihirbaran Mandal

Troy McCracken

Pawan Dhondi

Amjad Ali

Duane A Burnett

Dong Xiao

Michael Man-Chu Lo

Younong Yu

Pauline C Ting

Rongze Kuang

Johannes H Voigt

Theodros Asberom

Timothy J Henderson

Tao Yu

Yeon-Hee Lim

Jayaram R Tagat

Tanweer A Khan

Yonglian Zhang

Heping Wu

Xiaoxiang Liu

Gang Zhou

Thomas A Bara

Jianhua Cao

Joe F Lee

Mark D McBriar

Jae-Hun Kim

Jie Wu

Sylvia Joanna Degrado

Liwu Hong

Monica L Vicarel

Alexander L Tung

Dong Won-Shik Kim

Yushi Xiao

Troy M Mccracken

The present invention is directed to compounds of generic formula I: or pharmaceutically acceptable salts thereof that are believed to be useful as an A2A-receptor antagonist. 

[object Object]

In many embodiments, the present invention provides novel heterocyclic compounds which are modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more disease associated with the central nervous system using such compounds or pharmaceutical compositions.

Gamma secretase modulators

In its many embodiments, the present invention provides a novel class of heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.

This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of formula (I).

This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein Ris a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I). 

The present invention provides a novel class of heterocyclic compounds of Formula (I) as modulators of gamma secretase, wherein the definitions of the variables of Formula (I) are defined herein, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions. 

Disclosed are novel compounds of the formula or a pharmaceutically acceptable salt thereof, wherein: 

Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein:

Disclosed are compounds of the formula or a pharmaceutically acceptable salt or solvate thereof, wherein: and X is &#x2014;O&#x2014; or &#x2014;S&#x2014;; and X is &#x2014;O&#x2014;, &#x2014;S&#x2014; or &#x2014;NR&#x2014;; 

Growing community of inventors

Edison, NJ, United States of America

Xiaohong Zhu