Medtronic, Inc.

3m Innovative Properties Company

Biothera Inc.

Xiaohong Qiu

Keith B Gorden

Daniel C Sigg

Nandita Bose

John P Vasilakos

Jeremy Graff

Prasanga D Hiniduma-Lokuge

Nadine Ottoson

Steven M Leonardo

Ross Fulton

Adria Bykowski Jonas

Kathryn A Fraser

Takashi Kangas

Vinod Sharma

Anissa S H Chan

Anissa Sh Chan

Jason R Fink

Kevin S Gorski

Shalley K Gupta

Steven Leonardo

This disclosure relates to the combination of soluble &#x3b2;-glucan and immune suppression-relieving agents that affect the tumor microenvironment. Soluble &#x3b2;-glucan promotes an immunostimulatory environment, which allows enhanced effectiveness of anti-angiogenics, checkpoint inhibitors including non-tumor targeting antibodies.

&#x3b2;-glucan methods and compositions that affect the tumor microenvironment

The present invention relates to the combination of soluble &#x3b2;-glucan and anti-cancer agents that affect the tumor microenvironment. Soluble &#x3b2;-glucan promotes an immunostimulatory environment, which allows enhanced effectiveness of anti-cancer agents.

Beta-glucan in combination with anti-cancer agents affecting the tumor microenvironment

A delivery system for delivering a therapeutic agent to a patient includes a catheter, a stop feature, a container and a bar. The catheter has a proximal end and a distal end and includes a body defining a lumen that extends to the distal end of the catheter. The stop feature is in proximity to the distal end of the catheter. The container is configured to house the therapeutic agent and is insertable and slidably disposable in the lumen of the catheter. The container is also configured to engage the stop feature of the catheter. The bar is slidably disposable in the lumen of the catheter. Sliding of the bar distally in the lumen forces the therapeutic agent out of the container and out of the lumen when the container is engaged with the stop feature. The stop feature is configured to inhibit the container from exiting the lumen.

System and method for delivery of biologic agents

The method may include administering to a subject in need thereof an effective amount of an HCN polynucleotide. The HCN polynucleotide includes a nucleotide sequence encoding an HCN polypeptide having channel activity. The amino acid sequence of the HCN polypeptide and the amino acid sequence of a reference polypeptide have at least 80% identity, where the reference polypeptide begins with an amino acid selected from amino acids 92-214 and ends with an amino acid selected from amino acids 723-1188 of SEQ ID NO:8. An example of a reference polypeptide is amino acids 214-723 of SEQ ID NO:8. The HCN polynucleotide may be DNA or RNA.

Methods for treating cardiac pacing conditions

Methods of identifying a compound that selectively modulates at least one TLR-mediated cellular activity are disclosed. Generally, the methods include identifying a compound as a compound that selectively modulates at least one TLR-mediated cellular activity if the compound modulates one TLR-mediated cellular activity to a different extent than it modulates a second TLR-mediated cellular activity. Compounds so identified and pharmaceutical compositions including such compounds are also disclosed. Methods of selectively modulating immune cells and methods of treating certain conditions are also provided. Such methods include administering to cells or a subject a compound that selectively modulates a TLR-mediated cellular activity.

Selective modulation of TLR-mediated biological activity

Methods of eliciting a TLR8-mediated cellular response are disclosed. Such methods include administration of either a TLR8 agonist or a TLR8 antagonist to an IRM-responsive cell so that the IRM compound affects at least one TLR8-mediate cellular signaling pathway. In some cases, the method may provide prophylactic or therapeutic treatment for a condition treatable by modulating a TLR8-mediated cellular pathway.

Methods and compositions related to IRM compounds and Toll-like receptor 8

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Rosemount, MN, United States of America

Xiaohong Qiu