Shanghai Jiao Tong University

Sph No. 1 Biochemical & Pharmaceutical Co., Ltd.

Xiaohong Huo

Lu Zhang

Wanbin Zhang

Zhenfeng Zhang

Mo Wang

Qianjia Yuan

Jianzhong Chen

A method for catalytic asymmetric synthesis of a phosphorus-stereogenic (P-stereogenic) nucleoside derivative of formula (3) and a catalyst used therein. The P-stereogenic nucleoside derivative (3) can be hydrolyzed to obtain remdesivir. Specifically, a nucleoside and phosphoryl chloride are subjected to asymmetric reaction under the catalysis of a chiral bicyclic imidazole catalyst in the presence of a base to produce the P-stereogenic nucleoside derivative of formula (3) 

Method for catalytic asymmetric synthesis of phosphorus-stereogenic (P-stereogenic) nucleoside derivative and catalyst used therein

Growing community of inventors

Shanghai, China

Xiaohong Huo