Biogen Ma Inc.

Chemrus Inc.

Biogen Idec Ma Inc.

Boigen Ma Inc.

Liu, Xiaogao

Cai, Jianjian

Xiaogao Liu

Gnanasambandam Kumaravel

Kevin Guckian

Arthur G Taveras

Bin Ma

Guo Zhu Zheng

Richard Dana Caldwell

Edward Yin-Shiang Lin

Jermaine Thomas

Daniel M Scott

Wen-Cherng Lee

Zhan Shi

Jianjian Cai

Hairuo Peng

Ma Bin

Kevin M Guckian

A laboratory weighing kit comprises two layers: a disposable paper-structured weighing boat in the upper layer and a corresponding-shaped weighing base in the lower layer. The weighing boat has a sample loading portion in the rear to carry chemicals or samples, and a funnel portion in the front to transfer samples. In order to consolidate storage space, either the front funnel can be opened to two portions or the back wall of the weighing boat is opened. The weighing boat can be creased to form a permanent fold. The weighing boat in the upper layer can be either removable from or permanently attached to the weighing base in the lower layer.

Laboratory paper-structured weighing kit

Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.

Bicyclic aryl sphingosine 1-phosphate analogs

Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.

Heterobicyclic sphingosine 1-phosphate analogs

Compounds of formula (I) can modulate the activity of one or more S 1P receptors. Sphingosine 1-phosphate (S IP) is a lysophospholipid mediator that evokes a variety of cellular responses by stimulation of five members of the endothelial cell differentiation gene (EDG) receptor family, namely S1P1, S1P2, S1P3, S1P4, and S1P5 (formerly EDG1, EDG5, EDG3, EDG6 and EDG8). The EDG receptors are G-protein coupled receptors (GPCRs) and on stimulation propagate second messenger signals via activation of heterotrimeric G-protein alpha (Ga.) subunits and beta-gamma (G( )y) dimers.

S1P modulating agents

Disposable polymer-structured filter

The disposable polymer-structured filtering kit includes a disposable, polymer-structured filtering funnel with a stem having a distal tip. A flow discharge end is formed at the distal tip. Preferably, a polymer fritted filter disc is positioned in the funnel, providing filtering for liquids passing therethrough. The kit preferably also includes a glass vacuum take-off adapter having a port for connecting to a vacuum source for providing negative pressure. The adapter securely and snuggly receives the funnel and maintains position of the distal tip thereof with the flow discharge end below the port, thus preventing contaminants from entering the adapter. A reusable, glass round bottle flask or a disposable vial receives the adapter and the stem of the funnel. The funnel and fritted disc are formed from disposable materials, thus removing the necessity of cleaning them following use. The adapter is reusable, since no contaminants come in contact therewith during filtering.

Disposable polymer-structured filtering kit

Compounds that have agonist activity at one or more of the SIP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at SIP receptors.

Growing community of inventors

Dover, MA, United States of America

Xiaogao Liu