Wuhan University

Satellite Application Center for Ecology and Environment, Mee

Abmax Biotechnology Co., Ltd.

Xiaogang Zhang

Hao Sun

Chen Wang

Chao Wang

Nan Wang

Qian Zhao

Le Sun

Jianhui Zhang

Dan Xu

Bin Meng

Jixi Gao

Shoujing Yin

Maohua Li

Hongyan Yang

Yanting Wu

Xuelei Wang

Yihuang Nie

Cuijuan Zhang

Yaming Zhou

Xing Jia

Huan Zhao

The present disclosure provides a method, apparatus, medium and device for extracting a river drying-up region and frequency, and belongs to the technical field of remote sensing. The method for extracting a river drying-up region and frequency can be applied to efficiently acquiring river drying-up information for a long time within the large spatial region. With the inverse normalized difference water index (iNDWI) and the maximum value composite (MVC) method for the remote sensing images, the present disclosure omits the troublesome step of separately extracting a river range for each image in the conventional method. In addition, the present disclosure quickly obtains the drying-up frequency by counting the total number of available images and the number of non-water images at the same pixel position, and yields a greater efficiency for extracting the river drying-up region and frequency.

Method, apparatus, medium and device for extracting river drying-up region and frequency

Disclosed herein are low immunogenic human anti-TNF-&#x3b1;antibodies which can inhibit the apopotosis of cells induced by TNF-&#x3b1;. The invented low immunogenic human anti-TNF-&#x3b1; antibodies are capable of binding to TNF-&#x3b1; specifically. The invention presents the human anti-TNF-&#x3b1;antibodies which bind to TNF-&#x3b1; with similar affinities as Adalimumab. Most importantly, the invented human anti-TNF-&#x3b1; antibodies showed reduced immunogenicities in vivo, which made them safer candidate for antibody drug and other biotherapy. The invention also features method of de-immunogenicity of antibody drugs by identification, replacement of high immunogenic FR sequence(s) of the human antibody with low immunogenic FR sequences from other human IgGs, and significantly reduce the risk of human anti-human immunogenicity and improve the efficacy of antibody drugs.

Anti-TNF-&#x3b1; fully human monoclonal antibodies with low immunogenicity and application thereof

Growing community of inventors

Beijing, China

Xiaogang Zhang