Shanghai Kexin Biotech Co., Ltd.

Xiaofeng Zeng

Yue Zhang

Weina Situ

Hua Mao

Hongbin Sun

Jie Qian

Zhinan Shou

Yongjun Han

The present application provides compositions and methods useful for detecting and monitoring autoimmune diseases in a human subject. The methods comprise providing a moesin fragment for binding to an anti-moesin autoantibody and contacting the moesin fragment with a sample obtained from the human subject. The moesin fragment comprises the entire N-terminal FERM domain of a human moesin protein. The human subject has or is suspected of having an autoimmune disease such as connective tissue disease, systemic sclerosis, Sjogren's syndrome, or systemic lupus erythematosus.

Moesin fragments and uses thereof

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Shanghai, China

Xiaofeng Zeng