Transcend Therapeutics, Inc.

Xiaofeng Lin

Francis H Verhoff

Gordon J Rossiter

L Reade Baxley

Method for synthesizing L-2-oxothiazolidine-4-carboxylate and its acid, L-2-oxothiazolidine-4-carboxylic acid. The present invention involves the separation of phenol from a reaction mixture containing L-2-oxothiazolidine-4-carboxylate and phenol. In the present method a reaction mixture containing phenol, L-2-oxothiazolidine-4-carboxylate, and chloride salt, is contacted with a phenol adsorbing adsorption resin, the adsorption resin comprising a polymer having a polyethylene backbone. The adsorption resin is capable of adsorbing substantially all of the phenol while not adsorbing substantial amounts of the L-2-oxothiazolidine-4-carboxylate from the reaction mixture.

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Wesley Chapel, FL, United States of America

Xiaofeng Lin