Shanghai Synergy Pharmaceutical Sciences Co., Ltd.

Zhejiang Huahai Pharmaceutical Co., Ltd.

Xiaoer Xia

Xin Xu

Zhen Zhang

Yunfei Li

Jian Ge

Yijin Wang

Xiaojuan Zhang

Jia Chen

Liming Zhang

Qiang Li

Lei Liu

Fan Yang

Hao Yu

Dongsheng Li

Xiaobo Zhou

Kang Sun

Jiamiao Wang

Qingyun Jiang

Linli Zhang

Fengying Guo

Chenghao Xi

Chunqiao Chen

Yuyun Zhang

Minkai Qu

Qimei Wu

Chengxu Zang

Provided are amide compounds, a preparation method therefor, and use thereof in the medical field. Specifically, provided are small molecule amide compounds. Such compounds are inhibitors of enhancer of Zeste homolog 2 (EZH2), and can be used for preventing and/or treating related diseases mediated by EZH2, including tumors, myeloproliferative diseases or autoimmune diseases.

Amide compounds, preparation method therefor, and use thereof in the medical field

Related are a JAK kinase inhibitor, a preparation method for same, and applications thereof in the field of medicine, related to the field of medicinal chemistry. Provided is a novel small molecule JAK inhibitor, which has the structure as represented by formula (II). The compound provides improved efficacy and safeness in preventing or treating a JAK-related indication.

JAK kinase inhibitor, preparation method for same, and applications thereof in field of medicine

The present application provides a vortioxetine pamoic acid salt, which includes a crystal form, a solvate or an amorphous substance of the vortioxetine pamoic acid salt. The present application provides a preparation method and use of the vortioxetine pamoic acid salt and the crystal form thereof. The vortioxetine pamoic acid salt prepared in the present application prolongs the residence time of the vortioxetine in vivo, achieving a slow release of the vortioxetine in vivo, and is suitable for preparing a long-acting dosage form.

Vortioxetine pamoic acid salt and crystal form thereof

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Shanghai, China

Xiaoer Xia