General Electric Company

Xiaodong Tao

Ali Can

Michael John Gerdes

Musodiq O Bello

Maximilian Lewis Seel

Harvey E Cline

James Vradenburg Miller

Christopher Judson Hardy

Robert John Filkins

Robert David Darrow

Robert F Senzig

Francis Howard Little

Robert August Kaucic

Thomas K Foo

Luca Marinelli

Harry Israel Ringermacher

Patrick Joseph Howard

Donald Robert Howard

Paulo Ricardo Mendonca

Yanyan Wu

Vivek Prabhakar Vaidya

Michael Christopher Montalto

Kedar Bhalchandra Khare

Roshni Bhagalia

Zhaohui Harry Sun

Mukta Chandrashekhar Joshi

Matthew Edward Dragovich

Maggie M Fung

Eric Scott Foster

Francis Edward Pavan-Woolfe

Harvey Ellis Cline

Systems and methods for landmark correction in Magnetic Resonance Imaging (MRI) are provided. One method includes acquiring at least one calibration image or at least one localizer image of an object, identifying in the calibration or localizer images a region of the object as a reference point, wherein the reference point defines a landmark position. The method further includes determining an offset between an initial landmark position and the identified landmark position. The method also includes using the determined offset for MRI.

Systems and methods for landmark correction in magnetic resonance imaging

The present techniques include methods and systems for finding correspondences between tissue spots in tissue microarray serial sections belonging to the same recipient block. The present techniques may also be used to relate individual tissue cores to clinical information. Using either a whole slide image or the relative x-y coordinates of the tissue spots on the slide, individual tissue spots in different tissue microarrays may be linked to one another and their clinical information.

Method and apparatus for analysis of tissue microarrays

A method and system for registering two images is described. The method comprises synthesizing projections from two volumetric images to be registered, estimating a plurality of two dimensional (2D) deformable fields from the projections and generating a three dimensional (3D) deformable fields using a plurality of backprojections of the 2D deformable fields.

Image registration system and method

The present techniques provide systems and methods for registering images of tissue spots on a tissue microarray (TMA). In studies involving multiple biomarkers being studied on the same TMA, the TMA slide is removed from the microscope, stained, and then imaged, often multiple times. The present techniques relate to validation of the registration of the acquired images of the same TMA. An automatic approach to register the images and detect registration failures as provided herein may enhance the rapid analysis of the tissues. Artifacts such as tissue folding and tissue loss are also determined automatically.

Method and apparatus for detecting irregularities in tissue microarrays

A method for determining 3D distances on a 2D pixelized image of a part or object includes acquiring a real 2D pixelized image of the object, creating a simulated image of the object using the 3D CAD model and the 2D pixelized image, determining a specified cost function comparing the simulated image with the real 2D pixilated image and repositioning the simulated image in accordance with iterated adjustments of a relative position between the CAD model and the 2D pixilated image to change the simulated image until the specified cost function is below a specified value. Then, the workstation is used to generate a 3D distance scale matrix using the repositioned simulated image, and to measure and display distances between selected pixels on a surface of the real image using 2D distances on the 2D pixelized image of the object and the 3D distance scale matrix.

Methods and apparatus for measuring 3D dimensions on 2D images

The present techniques provide fully automated methods for quantifying the location, strength and percent of expressed target molecules or other biological markers in immunohistochemically stained biological samples. The samples may be automatically segmented, for example into subcellular compartments, from images of compartmental markers. Then, the distribution of a target molecule on each of these compartments is calculated that includes the percentage and strength of expression. This is different than existing intensity or ratio based methods where abundant low expression levels are indistinguishable from scarce high expression levels.

Methods for assessing molecular expression of subcellular molecules

A signal processing method include steps initializing a residual data signal representative of an acquired data signal, determining a significant coefficient corresponding to the residual data signal, updating the residual data signal using the significant coefficient to generate updated residual data signal, iteratively determining significant coefficients to generate a plurality of significant coefficients using the updated residual data signal, updating the plurality of significant coefficients by using a successive approximation technique, to improve the numerical accuracy of the significant coefficients and reconstructing a data signal using the updated plurality of significant coefficients.

System and method for processing data signals

Techniques for removing image autoflourescence from fluorescently stained biological images are provided herein. The techniques utilize non-negative matrix factorization that may constrain mixing coefficients to be non-negative. The probability of convergence to local minima is reduced by using smoothness constraints. The non-negative matrix factorization algorithm provides the advantage of removing both dark current and autofluorescence.

Method and apparatus for removing tissue autofluorescence

A system for analyzing tissue samples, that generally comprises, a storage device for at least temporarily storing one or more images of one or more cells, wherein the images comprise a plurality of channels; and a processor that is adapted to determine the extent to which a biomarker may have translocated from at least one subcellular region to another subcellular region; and then to generate a score corresponding to the extent of translocation.

Systems for analyzing tissue samples

A method of imaging comprises performing a scout image of an object and aligning major regions of interest within the object by comparing the scout image with a pre-determined atlas image. In a further embodiment, a method of imaging using a computed tomography (CT) scanner is provided and comprises performing a scout image of a subject and aligning major anatomical regions of interest within the subject by comparing the scout image with a pre-determined atlas image. Further, an imaging system for us with a computed tomography (CT) imaging device is provided and comprises a processor configured to perform aligning major anatomical regions of interest within a subject by comparing a scout image with a pre-determined atlas image, and wherein the major anatomical regions are used for automated localization for Scan Range and/or Exam split.

System and method for automated patient anatomy localization

Methods and systems for segmenting images, wherein the image pixels are categorized into a plurality of subsets using one or more indexes, then a log-likelihood function of one or more of the indexes is determined, and one or more maps are generated based on the determination of the log-likelihood function of one or more of the indexes.

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Niskayuna, NY, United States of America

Xiaodong Tao