Shenzhen Dbs Technology Co., Ltd.

The Second Affiliated Hospital of Guangzhou University of Chinese Medicine

Chinese Academy of Medical Sciences

Guangzhou University of Chinese Medicine

Guangdong Provincial Hospital of Tcm

The Second Clinical College of Guangzhou University of Chinese Medicine

Guangdong Provincial Academy of Chinese Medical Sciences

The Second Clinical College of Guangzhou University of Chinese Medecine

Xiaodong Han

Bo Liu

Yi Wang

Yiqi Yang

Yunshan Wu

Kai Wang

Wen Zhou

Jun Li

Yuanchao Li

Jinjian Lu

Fangfang Xu

Yuqin Zhang

Jinbao Deng

Wei Mao

Xianzhang Huang

Zhimin Yang

Quanfu Chen

Xusheng Liu

Liqiao Han

Hualun Liang

Lilan Wu

Xiaowan Wang

Peng Xu

Ennian Li

Runyue Huang

Bidan Zheng

Weiying Chen

Jinlang Zhong

Ruimin Tian

Electric suspension mountain skateboard

Scooter

Wireless remote control

Skateboard

Disclosed in the present invention is a new triptolide derivative as shown in formula (I). Also disclosed in the present invention are a preparation method for the compound and the medical use thereof in preparation of anti-cancer drugs. Triptolide acrylate of the present invention and a pharmaceutically acceptable salt thereof have anti-cancer activity, and after animal in-vivo experiments, can effectively inhibit tumor growth in animals. A plurality of in-vitro experiments proves that same can significantly increase the protein expression quantity of p53, promote the apoptosis of tumor cells, effectively inhibit the growth of the tumor cells, and have the effect of inhibiting metastasis of cancer cells. More importantly, the toxicity of the compound to normal cells is less than that of triptolide. 

Triptolide acrylate, preparation method therefor and use thereof

The disclosure relates to a low toxicneoglycosides, which is obtained by chemically processingglycosides and adding triptriolide. The disclosure also discloses the application of the low toxicneoglycosides. Theneoglycosides can effectively relieve renal pathological injury and urinary protein of nephrotic syndrome, attenuate the inflammatory level of the body, have obvious treatment effect on nephrotic syndrome, and have low toxicity and persistent effect.

Low toxic tripterygium neoglycosides, preparation method and application thereof

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Guangdong, China

Xiaodong Han