Shanghai Yao Yuan Biotechnology Co., Ltd.

Intel Corporation

Hangzhou Joinstar Biomedical Technology Co., Ltd.

Honeywell International Inc.

Xiaodong Chen

Tian Xu

Danyang Liu

Tongruei Raymond Li

Jieqing Fan

Yanfang Pan

Cong Xu

Justin Lipman

Rui Hu

Wenjie Xu

Guojin Shen

Xuyi Zhou

Longbin Hong

Songbing Zhou

Yang Liu

Lei Zhang

Shuai Chen

Alan Bruce Hickman

Wenwan Feng

Yunfei Zou

Binggang Wo

The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A, A, L, L, L, Z, Z, W, W, R, R, R, R, R, Rand Rare defined herein.

Compositions and methods of modulating the immune response by activating alpha protein kinase 1

A fixed wing unmanned aircraft and a method for operating the same are provided. The fixed wing unmanned aircraft may include, but is not limited to, a failure detection system configured to detect faults in one or more of the plurality of components, a capability evaluation system communicatively coupled to the failure detection system, the capability evaluation system configured to determine a capability level of the fixed wing unmanned aerial vehicle based upon the faults in the one or more of the plurality of components, and a trajectory generation system communicatively coupled to the failure detection system and the capability evaluation system, the trajectory generation system configured to generate a touch down trajectory for the fixed wing unmanned aerial vehicle based upon the determined capability level of the fixed wing unmanned aerial vehicle, wherein when the determined capability level is below a predetermined threshold, the touch down trajectory comprising a stall maneuver configured to minimize a lateral energy of the fixed wing unmanned aerial vehicle.

Unmanned aerial vehicle off-site landing system

The disclosure provides compositions and methods related to activating alpha-kinase 1 (ALPK1) for modulating an immune response and treating or preventing cancer, infection, inflammation and related diseases and disorders as well as potentiating an immune response to a target antigen. The disclosure also provides heterocyclic compounds of formula (I) as agonists of alpha protein kinase 1 (ALPK1) and their use in activating ALPK1, modulating an immune response and treating diseases such as cancer, wherein A, A, L, L, L, Z, Z, W, W, R, R, R, R, R, Rand Rare defined herein. 

Apparatuses, methods and storage medium associated with cluster computing are disclosed herein. In embodiments, a server of a computing cluster may include memory. input/output resources, and one or more processors to operate one of a plurality of application slaves of an application master; wherein the other application slaves are operated on other servers, which, together with the server, are members of the computing cluster. The server may further include a service assurance manager agent to manage allocation of the one or more processors, the memory and the input/output resources to the application slave, to assure compliance with a node level service level agreement, derived from an application level service level agreement, to contribute to proximate assurance of compliance with the application level service agreement; wherein the application level service agreement specifies the aggregate service level to be jointly provided by the application master and slaves. Other embodiments may be described or claimed.

Cluster computing service assurance apparatus and method

A fully automatic test card conveying apparatus for an instant testing instrument is used for conveying a test card and includes a test card conveying arm, frame, push rod, buffer support, buffer cartridge, and card extraction mechanism. A first electric motor, second electric motor, first sliding rail, and second sliding rail are provided on the arm. The frame is connected in a sliding manner to the first sliding rail via a sliding block, and connected to the first electric motor via a first synchronization belt. A stepping motor is provided on the sliding block and an output end of the stepping motor is connected to the frame. The push rod is connected in a sliding manner with the second sliding rail, and connected to the second electric motor via a second synchronization belt.

Fully automatic test card conveying apparatus for instant testing instrument

A shaking device for a fully-automatic instant check meter, which is used for shaking blood in a test tube uniformly. The shaking device comprises a frame body, a barcode printer, a first bracket, a second bracket, a rotating mechanism, a vacuum blood vessel shaking mechanism and a peripheral blood vessel shaking mechanism, wherein a first sliding rail, a first motor and a second motor are provided on the frame body; the rotating mechanism is connected to the first sliding rail in a sliding manner via a first sliding block and is connected to the first motor via a first synchronous belt; the vacuum blood vessel shaking mechanism is connected to the first sliding rail in a sliding manner via a second sliding block and is connected to a second motor via a second synchronous belt; the peripheral vessel shaking mechanism is arranged below the vacuum blood vessel shaking mechanism; and the barcode printer is arranged at one side of the frame body. The shaking device has a simple structure and a good shaking effect, and is safe and reliable.

Shaking device for fully-automatic instant check meter

A method and system for detecting and reducing data transfer congestion in a wireless access point includes determining a round-trip-time value for an internet control message protocol (ICMP) packet transmitted from a source computing device to a first computing device of a plurality of computing devices via the wireless access point. A data rate for data transmissions from the source computing device is increased to a value no greater than a peak data rate value if the round-trip-time is less than a first threshold value. The data rate is decreased if the round-trip-time value is greater than a second threshold value. Additionally, the peak data rate value may also be decreased if the round-trip-time value is greater than the second threshold value.

Method and system for access point congestion detection and reduction

Growing community of inventors

Shanghai, China

Xiaodong Chen