Elan Pharmaceuticals, Inc.

Imago Pharmaceuticals, Inc.

Xiaocong Michael Ye

Simeon Bowers

Anh P Truong

Albert W Garofalo

R Jeffrey Neitz

Danielle Aubele

Marc Adler

Andrei William Konradi

Christopher Michael Semko

Dean R Artis

Yong-Liang Zhu

Roy K Hom

John P Anderson

Gary D Probst

Jennifer Sealy

Robert Galemmo

Paul Beroza

Darren B Dressen

Ying-Zi Xu

Minghua Sun

Jenifer Lea Smith

Michael S Dappen

Raymond Ng

Robert A Galemmo, Jr

Danielle L Aubele

Maurizio Franzini

Jacek J Jagodinski

Dean Richard Artis, I

The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease. 

Substituted cinnolines as inhibitors of LRRK2 kinase activity

The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, E, E, R, R, Rand Rare defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

Inhibitors of polo-like kinase

The present invention provides compounds having a structure according to Formula (I): or a salt or solvate thereof, wherein ring A, X, R, R, R, R, Rand Rare defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

The current invention provides compounds having a structure according to Formulae 1, 2, 3, and 4: wherein the A-ring, B-ring, C-ring, m, n, R, R, and Rare as described in the specification. The invention also provides pharmaceutical compositions comprising compounds of Formulae 1, 2, 3, and 4, as well as methods of treating cognitive disorders, such as Alzheimer's disease. The invention further provides intermediates useful in preparing the compounds of Formulae 1, 2, 3, and 4.

N-sulfonamido polycyclic pyrazolyl compounds

The invention provides N-cyclic sulfonamido compounds of Formula I wherein A, B, R, R, R, R, Rand Rare as described in the specification. Compounds of Formula I are useful in treating or preventing cognitive disorders, such as Alzheimer's disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of preparing compounds of formula I, and methods of treating cognitive disorders, such as Alzheimer's disease.

5-(arylsulfonyl)-pyrazolopiperidines

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Palo Alto, CA, United States of America

Xiaocong Michael Ye