Gilead Sciences, Inc.

F. Hoffmann-la Roche Ag

Xiaochun Han

James G Taylor

Yan Lou

Hong Yang

Ana Zurisadai Gonzalez Buenrostro

Lan Jiang

Michael L Mitchell

Jiayao Li

Qiaoyin Wu

Jennifer R Zhang

Hyung-Jung Pyun

David Michael Goldstein

James Patrick Dunn

Hongyan Guo

Lianhong Xu

Ryan McFadden

Scott D Schroeder

Devan Naduthambi

David W Lin

Aesop Cho

Randall Halcomb

Stacy W Remiszewski

Dmitry Koltun

Richard Y Huang

Alam Jahangir

Hongtao Liu

Steven Gregory Mischke

Jie Xu

Gediminas J Brizgys

Eric Q Parkhill

Paul A Roethle

Michael R Mish

Hai Yang

Leyi Gong

David Sperandio

Xiaowu Chen

Gregory F Chin

Kerim Babaoglu

Wylie Solang Palmer

Hang Chu

Anna E Hurtley

Yunfeng Eric Hu

Humberto Bartolome Arzeno

Devleena M Shivakumar

Nathan D Shapiro

Christophe Michoud

Gregg M Schwarzwalder

Matthew J Von Bargen

Yingmei Qi

Zhenhong R Cai

Joan Heather Hogg

Suzanne M Szewczyk

Johannes H Voigt

Michael O' Neil Hanrahan Clarke

Teresa Alejandra Trejo-Martin

Salman Y Jabri

Jamie Geier Bates

Deborah Carol Reuter

Kenneth Carey Rupert

Ting Wang

Parcharee Tivitmahaisoon

Gregg M Schwarzwälder

Yurong Lai

Jake Cha

Tim Hansen

Brian J Kirby

Ryan Mcfadden

Richard Huang

Randall L Halcomb

Tania Silva

Shao-Yong Wu

Compounds for use in treating or preventing human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R, R, L, W, W, X, Y, and Z are as defined herein. Methods associated with the preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use

The present disclosure relates generally to certain tricyclic compounds, pharmaceutical compositions comprising said compounds, and methods of making said compounds and pharmaceutical compositions. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Substituted pyridotriazine compounds and uses thereof

The present disclosure relates generally to compounds, of Formula I Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

Bridged tricyclic carbamoylpyridone compounds and uses thereof

The present disclosure relates generally to compounds, of Formula I: Also disclosed are pharmaceutical compositions comprising said compounds and methods of making said compounds. The compounds of the disclosure are useful in treating or preventing human immunodeficiency virus (HIV) infection.

The invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating the proliferation of the HIV virus, treating AIDS or delaying the onset of AIDS symptoms in a mammal using compounds of Formula I.

HIV protease inhibitors

The present disclosure relates generally to thienopyrimidine compounds that bind to Acetyl-CoA Carboxylase (ACC) and act as inhibitors of ACC. The disclosure further relates to the use of the thienopyrimidine compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of ACC, including liver diseases such as non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

Thienopyrimidine derivatives as ACC inhibitors and uses thereof

The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating cancers.

Imidazopyrimidine derivatives

Compounds disclosed herein including compounds of formula I': and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.

Therapeutic compounds

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San Jose, CA, United States of America

Xiaochun Han