The Florida State University Research Foundation, Inc

Emory University

Children's Healthcare of Atlanta, Inc.

University of Delhi

Children's Heatlhcare of Atlanta

Xiaochuan Yang

Binghe Wang

Nanting Ni

Guojing Sun

Chunhao Yang

Chaofeng Dai

Sunny Manohar

Nitin Kumar

Alexander Draganov

Diwan S Rawat

Weixuan Chen

Muxiang Zhou

Lubing Gu

Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.

Anthraquinone analogs and methods of making and using thereof

Compounds having Formula I or II, and methods of making and using thereof, are described herein: 

Curcumin analogs and methods of making and using thereof

Growing community of inventors

Baltimore, MD, United States of America

Xiaochuan Yang