Calitor Sciences, LLC

Sunshine Lake Pharma Co., Ltd.

North & South Brother Pharmacy Investment Company Limited

Primy Corporation Limited

Xiaobo Li

Ning Xi

Minxiong Li

Tao Zhang

Haiyang Hu

Weilong Dai

Wuhong Chen

Yanjun Wu

Hao Jia Li

Tingjin Wang

Xuguang Zou

Knud Robert Samsing

Ju Peng

Changlin Bai

Venkat Tirunagaru

Donghua Ke

Zhuofei Chen

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof. They are useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.

Substituted heteroaryl compounds and methods of use

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.

A mixer connection mechanism convenient to be mounted on a countertop is provided, which may be provided to be mounted to a countertop of a sink having a mounting hole. The mixer connection mechanism includes a base seat, a locking device, a screw rod assembly, and a position-limiting blocking lever. The screw rod assembly and position-limiting blocking lever are arranged between the base seat and the locking device. When mounted, the screw rod assembly is screwed up by an operation above the countertop of the sink to allow the screw rod assembly to be rotated, whereby rotation of the locking device is limited by the position-limiting blocking lever. Further, the locking device moves towards the countertop of the sink and abuts against a lower surface of the countertop of the sink. Meanwhile, an abutting end at the bottom of the surrounding wall abuts against the countertop of the sink.

Mixer connection mechanism convenient to be mounted on countertop

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening the severity of a protein-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof useful in preventing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.

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Guangdong, China

Xiaobo Li