Abbott Laboratories Corporation

Xiaoan Ruan

Leonard Katz

Diane L Stassi

Ana Pereda-Lopez

Richard G Summers, Jr

Stephan J Kakavas

The invention provides novel erythromycin derivatives in which methyl groups on the macrolactone ring have been substituted with &mdash;H, -Et, and/or &mdash;OH. The invention also provides reagents such as isolated polynucleotides, vectors comprising the polynucleotides and host cells transformed with the vectors for making the novel compounds. Methods for making the compounds utilizing genetic engineering techniques are also disclosed.

Polyketide derivatives and recombinant methods for making same

The invention provides novel erythromycin derivatives in which methyl groups on the macrolactone ring have been substituted with --H, -Et, and/or --OH and the ethyl side-chain has been substituted with hydroxymethyl or dihydroxycyclohexylmethyl side-chains. The invention also provides reagents such as isolated polynucleotides, vectors comprising the polynucleotides and host cells transformed with the vectors for making the novel compounds. Methods for making the compounds utilizing genetic engineering techniques are also disclosed.

The invention provides novel erythromycin derivatives in which methyl groups on the macrolactone ring have been substituted with --H, --Et, and/or --OH. The invention also provides reagents such as isolated polynucleotides, vectors comprising the polynucleotides and host cells transformed with the vectors for making the novel compounds. Methods for making the compounds utilizing genetic engineering techniques are also disclosed.

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Lake Bluff, IL, United States of America

Xiaoan Ruan