University of Toronto

Other

Liu, Jiang

Wu, Xiao Yu

Johnston, Michael Richard

Xiao Yu Wu

Claudia Regina Gordijo

Alireza Shalviri

Huiyu Huang

Ping Cai

Kai Zhang

Frank Yam

Amin Ghavami Nejad

Brian Lu

Jason Li

Jason Siu-Wei Li

Adria Giacca

Michael Kl Chu

Michael Richard Johnston

Jiang Liu

A composition for preventing or treating hypoglycemia in a patient in need thereof has a microgel that includes crosslinked polymers containing glucose-responsive moieties; and blood glucose-raising therapeutic agent loaded on or within the microgel. The microgel further includes any one or a combination of a stabilizing component and a loading-assisting component for the blood glucose-raising therapeutic agent. The polymers containing the glucose-responsive moieties form secondary crosslinks in response to low glucose level, thereby causing shrinking of the microgel and rapid release of the blood glucose-raising therapeutic agent. The composition can be used to prepare a composite microneedle patch for preventing or treating hypoglycemia, where the composition is embedded or integrated within an array of the microneedles of the microneedle patch device.

Composition and device for preventing hypoglycemia and use thereof

Synthesis and characterization of starch based pH-responsive nanoparticles for controlled drug delivery are described. Polymethacrylic acid grafted starch (PMAA-g-St) nanoparticles with various molar ratio of starch to MAA were synthesized by a new one-pot method that enabled simultaneous grafting of PMAA and nanoparticle formation in an aqueous medium. NMR data showed that polysorbate 80 was polymerized into the graft polymer. Nanoparticles were relatively spherical with narrow size distribution and porous surface morphology and exhibited pH-dependent swelling in physiological pH range. The particle size and magnitude of volume phase transition were dependent on PMAA content and formulation parameters such as surfactant levels, cross-linker amount, and total monomer concentration. The results showed that the new pH-responsive nanoparticles possessed useful properties for controlled drug delivery.

Polymeric nanoparticles useful in theranostics

A biocompatible insulin delivery device is provided comprising an insulin reservoir sealed with a glucose-responsive plug or membrane. The plug functions to release insulin from the reservoir in response to a hyperglycemic glucose concentration and to prevent insulin release from the reservoir in response to hypoglycemic glucose concentration. In one embodiment, the plug is made of a biocompatible polymeric matrix comprising an inorganic component, a stimulus-responsive component and a catalytic component.

Implantable-glucose responsive insulin delivery device

Described is a composite polymeric system to provide enhanced stimuli-responsiveness. The first aspect provides particles where the particles are made of stimuli-responsive polymer which responds to various stimuli such as temperature and pH change. Incorporated with this particle is a second polymer which in turn is relatively insensitive to stimuli. The invention can be potentially applied to other systems comprising a swellable hydrogel and a nonswellable hydrophobic polymer.

Polymeric system for drug delivery and solute separation

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Toronto, Canada

Xiao Yu Wu