Nvidia Corporation

Jiangsu Hengrui Medicine Company Ltd.

Shanghai Hengrui Pharmaceutical Co., Ltd.

Xiao Wu

Shuai Wang

Rongzhe Zhu

Chen Yao

Yuji Qian

Xixi Xie

Feng He

Weikang Tao

Fanglong Yang

Jingjing Yan

Kun Yang

Xing Fan

Shanghai Yu

Weiping Pan

An indazole derivative, a preparation method therefor, and a pharmaceutical application thereof. In particular, the present invention relates to an indazole derivative represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, and a use of the derivative as an estrogen receptor modulator in the prevention and/or treatment of an estrogen receptor mediated or dependent disease or condition, the disease being particularly preferably breast cancer. The definition of each substituent in the general formula (I) is the same as that in the description.

Indazole derivative, preparation method therefor, and pharmaceutical application thereof

Disclosed are apparatuses, systems, and techniques to perform and facilitate secure ladder computational operations whose iterative execution depends on secret values associated with input data. Disclosed embodiments balance execution of various iterations in a way that is balanced for different secret values, significantly reducing vulnerability of ladder computations to adversarial side-channel attacks.

Techniques, devices, and instruction set architecture for balanced and secure ladder computations

Disclosed are apparatuses, systems, and techniques to perform and facilitate secure ladder computational operations whose iterative execution depends on secret values associated with input data. Disclosed embodiments use masking factors that re-blind secret data without exposing the unmasked secret data between iterations of the ladder computations. Some disclosed embodiments use Montgomery multiplication techniques to facilitate secret data masking by efficiently avoiding modular division operations. Disclosed embodiments significantly reduce the vulnerability of ladder computations to adversarial side-channel attacks.

Efficient masking of secure data in ladder-type cryptographic computations

Disclosed are apparatuses, systems, and techniques to perform and facilitate fast and efficient modular computational operations, such as modular division and modular inversion, using shared platforms, including hardware accelerator engines.

Techniques, devices, and instruction set architecture for efficient modular division and inversion

The present invention relates to a five-membered heteroaryl ring bridged ring derivative, a preparation method therefor and the medical use thereof. In particular, the present invention relates to a new five-membered heteroaryl ring bridged ring derivative as shown in formula (I), a preparation method therefor and a pharmaceutical composition comprising the derivative, and the use thereof as a therapeutic agent, in particular as a TGF-&#x3b2; inhibitor, and the use in the preparation of a drug for treating, preventing or reducing cancers mediated by the over-expression of TGF-&#x3b2;, wherein the definition of each substituent in the general formula (I) is the same as defined in the description. 

Five-membered heteroaryl ring bridged ring derivative, preparation method therefor and medical use thereof

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Shanghai, China

Xiao Wu