Glaxo Group Limited

Glaxosmithkline LLC

Xiao Qing Lewell

Keith Biggadike

Stephen Allan Smith

Diane Mary Coe

Charlotte Jane Mitchell

Naimisha Trivedi

Simon Teanby Hodgson

Graeme Michael Robertson

Duncan B Judd

Lee Andrew Harrison

Suzanne Elaine Keeling

Colin David Eldred

Stephen Swanson

Caroline Mary Cook

Paul Martin Gore

Rachael Anne Ancliff

Gerard Martin Paul Giblin

Alan Naylor

Andrew McMurtrie Mason

Simon John Fawcett MacDonald

David Nigel Hurst

Graham George Adam Inglis

Derek Anthony Demaine

Martin Edward Swarbrick

Adrian Hall

Ian Reginald Kilford

Andrew John Walker

Mark Wilkinson

Rachael Ann Ancliff

Martin Alistair Hayes

Gail Mills

Rachel Elizabeth Hosking

Riccardo Novelli

Duncan Bruce Judd

Compounds of formula (I): wherein Ris Calkylamino, Calkoxy, or Ccycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

6-amino-purin-8-one compounds

The present invention relates to compounds of formula (I): wherein Ris Calkylamino, Calkoxy, or Ccycloalkyloxy; m is an integer having a value of 3 to 6; n is an integer having a value of 0 to 4; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases

Morpholinyl-urea derivatives for use in the treatment of inflammatory diseases

There are provided according to the invention, novel compounds of formula (I) wherein R, R, R, R, R, X, a, b and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

Morpholin-acetamide derivatives for the treatment of inflammatory diseases

Compounds of formula (I) or salts or solvates thereof or physiologically functional derivatives thereof are potent binders at the EP4 receptor and are of use in the treatment or prevention of conditions such as a pain, inflammatory, immunological, bone, neurodegenerative or renal disorder.

Indole derivatives

Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, R, R, R, R, Rand n are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.

(2-((2-alkoxy)-phenyl) -cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives

There are provided according to the invention, novel compounds of formula (I) wherein R, R, R, R, R, R, X, a, b and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

Compounds useful in the treatment of inflammatory diseases

The present invention relates to novel morpholin-acetamide compounds of formula (I) useful for the treatment of inflammatory diseases. Compounds of formula (I)wherein R, R, R, R, R, X, a, b and Z are as defined in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

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Stevenage, United Kingdom

Xiao Qing Lewell