University of Southern California

Xiao-Nan Zhang

Yong Zhang

Zhefu Dai

This disclosure provides a method of synthesis of 4'-thioribose NAD+ and analogues thereof, using an efficient chemoenzymatic approach. Also provided are methods of inhibiting the CD38 enzyme and compounds including 4&#x2032;-thioribose NAD+ and compounds related thereto.

4-thioribose NAD analogues and methods of synthesizing and using the same

Antibody-drug conjugates, compositions thereof, and methods use. The antibody-drug conjugates include a fusion protein comprising an antibody covalently linked to an ADP-ribosyl cyclase protein via a peptide linker moiety at one or more of a C-terminus or N-terminus of a heavy or light chain of the antibody, a NAD or NMN analogue, and a payload such that the NAD or NMN analogue is conjugated to both the payload and the ADP-ribosyl cyclase protein.

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Los Angeles, CA, United States of America

Xiao-Nan Zhang