The United States of America, as Represented by the Secretary, Department of Health and Human Services

Loyola University of Chicago

Xiao Lu

Wei Ping Zheng

Wenwei Huang

Philip Edward Sanderson

Xiuli Huang

Gregory J Tawa

Kim C Williamson

Hao Li

Paresma R Patel

Hangmao Sun

Myunghoon Kim

Meghan J Orr

Wei Sun

Disclosed are compounds of formula (I) and formula (II): wherein R, R, A, and B are as defined herein. Also disclosed is a method of blocking transmission of aparasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.

Compounds and method for blocking transmission of malarial parasite

Disclosed are compounds of formula (I) and formula (II): (I) (II) wherein R, R, A, and B are as defined herein. Also disclosed is a method of blocking transmission of aparasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat. 

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Rockville, MD, United States of America

Xiao Lu