Hoffmann-La Roche Inc.

Genentech, Inc.

Ventana Medical Systems, Inc.

Xiao Li

Yao Nie

Fabien Gaire

Jacob Gildenblat

Ido Ben-shaul

Trung Kien Nguyen

Ofir Etz Hadar

Systems and methods relate to predicting disease progression by processing digital pathology images using neural networks. A digital pathology image that depicts a specimen stained with one or more stains is accessed. The specimen may have been collected from a subject. A set of patches are defined for the digital pathology image. Each patch of the set of patches depicts a portion of the digital pathology image. For each patch of the set of patches and using an attention-score neural network, an attention score is generated. The attention-score neural network may have been trained using a loss function that penalized attention-score variability across patches in training digital pathology images labeled to indicate no or low subsequent disease progression. Using a result-prediction neural network and the attention scores, a result is generated that represents a prediction of whether or an extent to which a disease of the subject will progress.

Attention-based multiple instance learning

Growing community of inventors

Foster City, CA, United States of America

Xiao Li