Genetics Institute, Inc.

Xiao-Jia Chang

Ravindra Kumar

Dianne S Sako

Geertruida Machteld Veldman

Glenn R Larsen

Gray D Shaw

Dale Anthony Cumming

Ray Camphausen

A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.

P-selectin ligand protein

Nucleic acids encoding P-selectin ligand fusion proteins

Fusions proteins comprising P-selectin ligand proteins are disclosed, including fusions with immunoglobulins, BMPs, AGP and IL-11. Polynucleotides encoding such fusions are also disclosed.

Fusions of P-selectin ligand protein and polynucleotides encoding same

Nucleic acid encoding a novel P-selectin ligand protein

Method of inhibiting P-selectin ligand activity

Growing community of inventors

Newton Centre, MA, United States of America

Xiao-Jia Chang