University-industry Cooperation Group of Kyung Hee University

Dong-a St Co., Ltd.

Xiao Fei Du

Eunjin Kim

Youngmi Kim

Ja Young Ryu

Jin Seok Jeong

Young Woong Cho

Sang Zin Choi

Mi Won Sohn

Myung Sook Oh

Jeong Soo Kim

Seon-Pyo Hong

Hai Hua Jiang

Byoung Moon Kim

The present invention relates to a pharmaceutical composition for treating and preventing degenerative neurological disorders, containing, as an active ingredient, a mixture extract of two or more types selected from the group consisting of Moutan Root Bark, Angelica Dahurica Root, and Bupleurum Root, or a fraction thereof. Specifically, the extract of the mixture of the present invention exhibits a recovery effect on mitochondrial function damage, a relieving effect on endoplasmic reticulum stress and also exhibits simultaneously an inhibitory effect on inflammatory response, which are remarkably improved compared with those exhibited in an in vitro single extract, and the extract of the mixture significantly exhibits an improvement effect on motor coordination and a protective effect on dopaminergic neurons in a Parkinson's disease animal model, and thus the extract of the mixture of the present invention or a fraction thereof can be useful as an active ingredient of a pharmaceutical composition for treating and preventing degenerative neurological disorders.

Pharmaceutical composition containing combination extracts of Moutan Root Bark, Angelica Dahurica Root, bupleurum root or fractions thereof for prevention and treatment of neurodegenerative disorder

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Yongin-si, South Korea

Xiao Fei Du