Transtech Pharma, Inc.

Xiao-Chuan Guo

Adnan M M Mjalli

Robert Carl Andrews

David R Jones

Suparna Gupta

Ramesh Gopalaswamy

Guoxiang Huang

Anitha Hari

Ghassan Qabaja

Xin Chen

Daniel Peter Christen

Christopher Behme

Robert Rothlein

Devi Reddy Gohimmukkula

Sameer Tyagi

Kwasi A Avor

Tripura Yaramasu

Mustafa Guzel

Mohan Rao

Muralidhar Bondlela

Murty N Arimilli

Kwasi S Avor

Adnan M Mjalli

Kwasi Avor

This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, &#x3b2;-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.

Azole derivatives and fused bicyclic azole derivatives as therapeutic agents

This invention provides aryl and heteroaryl compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention may be antagonists, or partial antagonist of factor IX and/or factor XI and thus, may be useful for inhibiting the intrinsic pathway of blood coagulation. The compounds may be useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway.

Aryl and heteroaryl compounds, compositions, and methods of use

This invention provides aryl and heteroaryl compounds of Formula (I) as described herein, and methods of their preparation. Also provided are pharmaceutical compositions made with the compounds of Formula (I) and methods for making such compositions. Compounds of Formula (I) may be useful for treating viral infections including orthopox viruses, either alone or in combination with other therapeutic agents.

This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as antagonists, or more preferably, partial antagonist of factor IX and thus, may be used to inhibit the intrinsic pathway of blood coagulation. The compounds are useful in a variety of applications including the management, treatment and/or control of diseases caused in part by the intrinsic clotting pathway utilizing factor IX. Such diseases or disease states include stroke, myocardial infarction, aneurysm surgery, and deep vein thrombosis associated with surgical procedures, long periods of confinement, and acquired or inherited pro-coagulant states.

Aryl and heteroaryl compounds and methods to modulate coagulation

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High Point, NC, United States of America

Xiao-Chuan Guo