Zhejiang Jiuzhou Pharmaceutical Co., Ltd.

Zhejiang Jiuzhou Pharmaceuticals Co., Ltd

Xianyi Zhang

Daqing Che

Yuanqiang Li

Hongjun Gao

Bin Zhang

Pucha Yan

Yunyu Hua

Xiaowei Hu

Shaoqing Ge

The present invention relates to the technical field of ibrutinib, particularly to the technical field of ibrutinib intermediate compounds and preparation methods thereof. The intermediate compounds are represented by formula A, wherein, the dotted line represents a double bond or a single bond between carbon and oxygen. 

Ibrutinib intermediate compounds, preparation methods and uses thereof

Disclosed are a silodosin intermediate and a preparation method thereof. The silodosin intermediate has the structure shown by the formula (A). X is hydrogen or bromide and Ris hydrogen. The formyl group may be a group having the structure shown by the formula I. Ris a protecting group of carboxyl, and Ris 3-hydroxypropyl or a group having the structure shown by the formula II. W is a protecting group of hydroxyl. A compound of the formula (A) according to the present invention may further be used for preparing a compound having the structure shown by the formula (D). By means of the intermediate and the preparation method therefor provided by the present invention, high-purity optically pure silodosin can be obtained, and the optical purity is above 99%. 

Silodosin intermediate and preparation method therefor

A new compound is provided, which is used for preparing lacosamide. A novel method for preparing lacosamide is also provided. During the reaction, iodomethane and silver oxide that are cost expensive are not used, nor a Pd-c catalyst is used, so the production cost is low, the raw materials and accessory materials are cheap and easily available, and the process is simple, so that industrial production is easy to realize; and moreover, the yield is high, and good economic efficiency can be achieved. 

Lacosamide intermediate compound, preparation method thereof and use thereof

Growing community of inventors

Taizhou, China

Xianyi Zhang