Genentech, Inc.

Xianrui Zhao

Frederick Cohen

Cuong Q Ly

Joseph P Lyssikatos

Anthony A Estrada

Snahel Patel

Daniel Fred Ortwine

Zhonghua Pei

Michael Siu

Michael F T Koehler

Philippe Bergeron

Malcolm Huestis

Kevin Hon Luen Lau

The present invention provides for compounds of Formula I and various embodiments thereof, and compositions comprising compounds of Formula I and various embodiments thereof.  In compounds of Formula I, the groups R, R, R, R, R, R, m, n and the C-linked Ring have the meaning as described herein. The present invention also provides for methods of using compounds of Formula I and compositions comprising compounds of Formula I as DLK inhibitors and for treating neurodegeneration diseases and disorders.

Substituted dipyridylamines and uses thereof

Disclosed are compounds of Formula I, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR). 

Pyrimidine compounds, compositions and methods of use

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San Mateo, CA, United States of America

Xianrui Zhao