The Scripps Research Institute

Blackthorn Therapeutics, Inc.

F. Hoffmann-la Roche Ag

Neumora Therapeutics, Inc.

Xianrui Zhao

Eric Douglas Turtle

Edward Roberts

Hugh Rosen

Miguel A Guerrero

Mariangela Urbano

Candace Mae Laxamana

Malcolm Huestis

Compounds are provided that antagonize the kappa-opioid receptor (KOR) and products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof: wherein X, Y, R, R, R, R, R, R, Rand Rare as defined herein.

Kappa opioid receptor antagonists and products and methods related thereto

Compounds are provided that antagonize the kappa-opioid receptor (KOR) and products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof: wherein X, Y, R, R, R, RR, R, Rand Rare as defined herein.

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South San Francisco, CA, United States of America

Xianrui Zhao