Sts Biopolymers, Inc.

Angiotech Biocoatings, Inc.

Xianping Zhang

Richard J Whitbourne

Michael R Violante

Daniel G Hullihen

Guo-Bin Wang

Frank Guo-Bin Wang

Generally, the present invention provides devices and methods for delivering high, efficacious concentrations of therapeutic agents, i.e., medicaments such as drugs, antibiotics, etc., to specific sites in a patient's body, such as tumors and infected lesions. In one aspect of the present invention there are provided devices to accomplish the aforesaid delivery of therapeutic agents and methods to accomplish the delivery by positioning a device in the body using minimally invasive techniques such as, for example, catheterization or via trochar. The devices may contain a carrier substrate and a coating on the substrate. The carrier substrate provides structural integrity to the device and the coating thereon contains at least one layer of polymeric material containing one or more medicaments. Optionally, there may be a non-medicated binder coat between the carrier substrate and the medicated polymer layer. The medicated polymer layer may contain a hydrophilic/hydrophobic polymer composition.

Targeted therapeutic agent release devices and methods of making and using the same

A part that can be introduced and/or implanted in the body, in body parts, or in body cavities, made of nonmetallic material or having a nonmetallic surface is designed such that infections associated with the use of parts of this type are reduced or entirely eliminated. This is achieved due to the fact that the entire surface of this part or parts or, depending on the effect, partial areas of this part or parts, that are nevertheless not in geometric contact, is/are furnished with a metallization ( ). It is also possible that the material at least in the area of its exterior surface ( ) contains metallic particles ( ) in powder or granular form made of a metal having an oligodynamic effect, and that the most exterior metallic particles ( ) are uncovered at least partially at the surface.

Anti-infective covering for percutaneous and vascular access device and coating method

The invention includes a method of coating a substrate, comprising exposing a substrate to an initiator capable of initiating a graft polymerization reaction on the substrate, to generate reactive radical sites on the surface of the substrate; contacting the substrate with a composition comprising one or more monomers in a medium which has different hydrophilicity compared to the substrate, and grafting monomer molecules onto the substrate by forming covalent bonds between monomer molecules and the substrate at reactive radical sites on the substrate surface. With the invention, novel coated articles can be obtained which are particularly usefull as medical products such as catheters.

Graft polymerization of substrate surfaces

The adherent coating of the invention comprises a stabilizing polymer together with an active agent (a hydrophilic polymer and/or a bioactive agent) in a layer bonded to the surface of a medical device. This invention encompasses the coating liquids used for coating medical devices, methods of coating the devices, and the coated devices. The stabilizing polymer is selected to entrap the active agent in a coating that has a high degree of flexibility and has improved bonding to a wide variety of substrates. Preferred stabilizing polymers are cross-linkable acrylic and methacrylic polymers, ethylene acrylic acid copolymers, styrene acrylic copolymers, vinyl acetate polymers and copolymers, vinyl acetal polymers and copolymers, epoxy, melamine, other amino resins, phenolic polymers, copolymers thereof, and combinations.

Adherent, flexible hydrogel and medicated coatings

According to the invention, hydrating agents in ultrafine form may be incorporated in an organic coating solution with a uniform distribution that does not change due to settling. In preferred embodiments, the coating solution comprises salt dissolved in an appropriate organic solvent blend. In another embodiment, the hydrating agent may be in the form of ultrafine particles dispersed in the polymer solution. The dispersion may be obtained by adding a stream of the aqueous hydrating agent solution to the organic polymer solution in a controlled fashion, or salt particles may be formed in the polymer solution by acid-base neutralization in solution. The coating solutions are storage stable. When applied to a medical device, the coating solution produces a homogenous coating with desirable performance characteristics. The coatings of the invention adhere to the substrate but not to moist tissue with which they are placed in contact. The coatings of the invention provide indwelling devices with long-lasting lubricity after the device is inserted in a body.

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Webster, NY, United States of America

Xianping Zhang