Painceptor Pharma Corporation

Xiannong Chen

Ashok Tehim

A pharmaceutical composition comprising a compound of Formula I wherein Ris selected from, inter alia, alkyl, aryl-loweralkyl, heterocycle-loweralkyl, loweralkyl-carbonate; optionally substituted amino; benzimidaz-2-yl; optionally substituted phenyl; loweralkyl-(R)(R) wherein one of Rand Ris selected from H and and the other is selected from carboxy, carboxy-loweralkyl and lower alkoxycarbonyl; NHCHCHOX wherein X represents an in vivo hydrolyzable ester; and Rand Rare independently selected from H, NO, halo, di(loweralkyl)amino, cyano, C(O)OH, phenyl-S-, loweralkyl, and Z(O)ORwherein Z is selected from C and S and Ris selected from H, lower alkylamino and arylamino; or pharmaceutically acceptable salts or certain in vivo hydrolyzable esters or amides thereof, in an amount effective to inhibit neurotrophin-mediated activity, and a suitable carrier, is described. The compositions are useful to inhibit undesirable neurotrophin-mediated activity such as the neurite outgrowth that occurs in some neurodegenerative disease states.

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Alpharetta, GA, United States of America

Xiannong Chen