Edison Pharmaceuticals, Inc.

Xianming Jin

Wei Zhang

Bing Wang

Jian Chen

Jiangao Song

Gail Walkinshaw

Donald R James

Xianfeng Li

Sekhar S Boddupalli

Arkadij M Elizarov

The invention relates to novel chroman derivatives, stereoisomers and pharmaceutically acceptable salts of Formula I wherein the substituents are as defined in the specification. They are useful in the treatment of disorders mediated by lipoxygenase, such as immune diseases, respiratory diseases and cardiovascular diseases, as well as in the treatment of neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.

Chroman derivatives

7,8-Bicyclic-chroman derivatives of Formula I: wherein the substituents are defined as in the specification or the pharmaceutically acceptable salts thereof, are disclosed. They are useful for the treatment of inflammatory disorders, neurodegenerative disorders and/or mitochondrial disorders. They are also useful in the manufacture of pharmaceutical formulations for the treatment of such conditions.

7,8-bicycloalkyl-chroman derivatives

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Fremont, CA, United States of America

Xianming Jin