Chinese Academy of Sciences

Xiankun Tong

Jianping Zuo

Youhong Hu

Wei Tang

Li Yang

Dong Lu

Bo Chao

Limin Zeng

Feifei Liu

Peilan He

Wuhong Chen

Dewen Li

Feihong Ji

Yunzhe Zhang

Provided are a phthalazinone compound, method for preparation thereof, pharmaceutical composition thereof, and a use thereof; the structure of said phthalazinone compound is as represented by formula I; the compound of said formula I is targeted to a viral nucleocapsid; it can inhibit the replication of a virus by means of interference of the viral nucleocapsid, has a potent activity for inhibiting HBV DNA replication and a good liver targeting, can stably exist and enrich in the liver, and is a new and effective anti-HBV inhibitor. 

Phthalazinone compound, method for preparation thereof, pharmaceutical composition thereof, and use thereof

Disclosed is a use of a quinazoline compound of Formula I having 2,4-diaminoquinazoline as a parent nucleus in preparation of a medicament for treating diseases caused by flaviviridae infection, especially a use in combating Hepatitis C virus infection and Dengue fever virus infection. 

Use of a quinazoline compound in preparing a medicament against flaviviridae virus

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Xiankun Tong