Chengdu Olymvax Biopharmaceuticals Inc.

Xiankai Liu

Xin Li

Bin Wang

Li Zhu

Peng Sun

Jun Wu

Ming Zeng

Erling Feng

Chao Pan

Hengliang Wang

Zhicheng Liu

Dongshu Wang

The present invention discloses aimmunogenic protein and its composition and application. This invention provides a protein, comprising 39 amino acids of the N-terminal α-helix part of the Ata protein transport functional domain ofand an adjuvant protein; amino acid sequence of said 39 amino acids of the N-terminal α-helix part of the Ata protein transport functional domain ofis shown as the 127-165amino acid residues of SEQ ID NO:2. In present invention the 39 amino acids of the N-terminal α-helix part of surface protein Ata (trimeric autotransporter) of, was took to fuse with CTB, and express in BL21. The protein was purified by a nickel column, and used to intraperitoneally immunize mouses by 2.5 μg/mouse. Its immunogenicity and immunoprotection was verified through the animal experiments, which proves it has a good effect of anti-infection of

immunogenic protein and composition and application thereof

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Beijing, China

Xiankai Liu