Apsam Imaging Corp.

Xiangxue Wang

Jun Xu

Anant Madabhushi

Kazuaki Nakane

Yao Fu

Haoda Lu

Michael D Feldman

Chaoyang Yan

Xiangshan Fan

The degree of differentiation of a cell in tissue is precisely determined. An estimating device () includes: a binarizing section () configured to generate binarized images from an image obtained by capturing an image of tissue; a Betti number calculating section () configured to calculate, for each binarized image, (i) the number of hole-shaped regions (b) each surrounded by pixels of a first pixel value and each composed of pixels of a second pixel value, (ii) the number of connected regions each composed of the pixels of the first pixel value connected together, and (iii) a ratio (R) between (i) and (ii); a statistic calculating section () configured to calculate statistics of the calculated numbers (b, b) and ratio (R); and an estimating section () configured to feed input data including the calculated statistics to a trained estimating model to output the degree of differentiation of the cell in tissue.

Image analysis method, estimating device, estimating system, and storage medium

Growing community of inventors

Cleveland, OH, United States of America

Xiangxue Wang