The Johns Hopkins University

Memorial Sloan Kettering Cancer Center

Ventana Medical Systems, Inc.

Xiangxue Wang

Jim F Martin

Wenjun Zhang

Lidija Pestic-Dragovich

Mehrnoush Khojasteh

Lei Tang

Luis Diaz

Robert Anders

A scoring functions is developed and used for identifying patients who might be responsive to a PD-1 axis directed therapy. The scoring functions are obtained by extracting features from multiplex-stained sections, selecting features that correlate with response to the therapy using a feature selection function, and fitting one or more of the selected features to a plurality of candidate scoring functions. A candidate scoring function showing the desired balance between predictive sensitivity and specificity may then selected for incorporation into a scoring system that includes at least an image analysis system.

Methods and systems for predicting response to PD-1 axis directed therapeutics

Growing community of inventors

Tucson, AZ, United States of America

Xiangxue Wang