Aputure Imaging Industries Co., Ltd.

Syz Cell Therapy Co.

Hryz (shenzhen) Biotech Co.

Hry Z (guangzhou) Biotech Co.

Hry Z (shanghai) Biotech Co.

Xiangjun Zhou

Yanyan Han

Yi Xie

Longqing Tang

Dongyun Wu

Yi Huang

Jin Li

Junyun Liu

Xihe Chen

Haijun Gu

Ran Tao

Kun Tong

Xiaoling Liang

Ziping Fu

Chongbo Huang

Fuping Liu

Zhouzhou Yin

Yifan Ma

Aimin Zhang

Provided methods of obtaining a plurality of T cell receptors specifically recognizing a target tumor antigen peptide from an individual that has clinically benefitted from an immunotherapy, such as Multiple Antigen Specific Cell Therapy. Also provided tumor-specific TCRs, engineered immune cells expressing the TCRs and methods of treating a disease using the engineered immune cells.

Methods of obtaining tumor-specific T cell receptors

The present invention provides a method of treating a cancer in an individual using activated T cells or PBMCs induced by antigen presenting cells (such as dendritic cells) loaded with a plurality of tumor antigen peptides. The method may further comprise administration of the antigen presenting cells loaded with the plurality of tumor antigen peptides to the individual. The methods may be used singly or in combination with an immune checkpoint inhibitor. Precision therapy methods customized for the individual using neoantigen peptides or based on the mutation load in the tumor of the individual are provided. Methods of preparing the activated T cells, methods of monitoring the treatment, and methods of cloning tumor-specific T cell receptors are further disclosed. An isolated population of cells comprising the activated T cells, as well as compositions and kits useful for cancer immunotherapy are also provided.

Methods of cancer treatment using activated t cells

The present invention belongs to the technical field of audio equipment, and particularly relates to a wireless microphone device and a use method therefor. In the wireless microphone device, a main control unit controls a transmitter working mode in which an input unit, an output unit, a time code unit, a conversion modulation unit, a storage unit and a radio-frequency unit work together; or a receiver working mode in which the input unit, the output unit, the time code unit, the conversion modulation unit and the radio frequency unit work together; or a time code generator working mode in which the output unit and the time code unit work together; or a sound recorder working mode in which the input unit, the time code unit, the conversion modulation unit and the storage unit work together.

Wireless microphone device and use method therefor

This application provides a power supply system. The power supply system includes a first device and a second device. The first device may be one of a control device and a film-and-television light, and the second device may be the other of the control device and the film-and-television light. The first device includes a first housing, a first coupler socket, a power supply circuit and a first set of contacts. The second device includes a second housing, a second coupler socket, a power receiving circuit, and a second set of contacts. In the power supply system. The power supply circuit in the first device and the power receiving circuit in the second device can be electrically connected through the first set of contacts in stalled on the first coupler socket and the second set of contacts installed on the second coupler socket.

Power supply system

A microphone is provided, which includes: a housing; at least one sound-pickup member disposed on the housing and configured to collect an external sound source; and a control circuit board disposed in the housing and in electrical connection to the at least one sound-pickup member; wherein the control circuit board comprises at least one input jack, and the at least one input jack is configured to operably connect with an external plug to collect other sound source different with the external sound source. In a detailed application, when the at least one sound-pickup member comprises at least two sound-pickup members, the control circuit board is configured, once a selection module of the control circuit board is triggered, to selectively output external sound sources collected by one or more of the at least two sound-pickup members and/or the other sound source collected by the at least one input jack.

Microphone

Disclosed are a heat dissipation device () and a lighting device (). The heat dissipation device () comprises a substrate (), a plurality of fins () and at least one airflow generating device (), wherein the plurality of fins () are arranged on the substrate () at certain intervals and are connected to the substrate (); and the at least one airflow generating device () is arranged at the ends of the plurality of fins () away from the substrate (), and an airflow generated by the airflow generating device () flows through at least some gaps of the plurality of fins () in the direction of the substrate () and is jointly guided by the substrate () and the plurality of fins () to be diffused.

Heat dissipation device and lighting device

The present disclosure provides a hot-swap circuit and a control apparatus. The hot-swap circuit includes: a power input terminal, a power output terminal; a startup module electrically connected to the power input terminal and the power output terminal; a switch module electrically connected to the power input terminal, the power output terminal, and the startup module; a detection module electrically connected to the startup module, the switch module, and the power output terminal. When a surge signal is input at the power input terminal, a voltage value of a first control signal output by the detection module doesn't fall in a voltage value range of a preset first control signal, then the switch module is controlled to be turned off, so as to cut off a power signal input to the power output terminal, reducing probability of circuit damage, and reducing sparking phenomena of hot-swap power interfaces.

Hot-swap circuit and control apparatus

The present application relates to the technical field of electronic circuits, and provides a charge circuit, a control box and a luminaire. The charge circuit includes a control circuit and at least one constant current charge circuit. The constant current charge circuit is electrically connected to the rechargeable battery. The control circuit is used to obtain the specification information of the rechargeable battery, and configure the corresponding charging parameters to be sent to the corresponding constant current charge circuit, so as to charge the rechargeable battery through the constant current charge circuit. As a result, the effect of automatically recognize rechargeable batteries of different specifications can be realized, and meet the situation where the rechargeable batteries of different specifications can be simultaneously charged through multiple channels, which solves the problem that the existing technology of lithium battery charging cannot satisfy simultaneously charging lithium batteries of different specifications.

Charge circuit, control box and luminaire

The present disclosure provides a lighting device and a power switching circuit. The power switching circuit of the lighting device includes a plurality of power input circuits and a logic control circuit. The logic control circuit is configured to receive a first electrical signal, a second electrical signal, or a third electrical signal, and control a first-switching circuit electrically connected with an Nth power input terminal to be turned on according to the first electrical signal, control the first-switching circuit electrically connected with the Nth power input terminal to be turned off according to the second electrical signal, and control a first-switching circuit electrically connected with first to (N&#x2212;1)th power input terminals to be turned off according to the third electrical signal; N is a positive integer less than or equal to a number of the power input circuits.

Lighting device and power switching circuit

A lighting device includes a light source and a power switching circuit including a plurality of power input circuits. Each of the power input circuits includes a power input terminal and a switch control circuit connected in series between the power input terminal and the light source. A control terminal of Nth switch control circuit controls the Nth switch control circuit to be turned off according to a first electrical signal input by first to (N-1)th power input terminals. The control terminal of the Nth switch control circuit controls the Nth switch control circuit to be turned on according to a second electrical signal being input by Nth power input terminal, and controls the first to (N-1)th switch control circuits to be turned off. The N is a positive integer greater than 1. A power switching circuit is also provided.

The present application provides methods of preparing tumor antigen-specific T cells comprising enriching activated T cells from a first co-culture comprising a first population of antigen-loaded dendritic cells loaded and a population of T cells, and co-culturing the enriched activated T cells with a second population of antigen-loaded dendritic cells. Also provided are methods of treating cancer in an individual using the tumor antigen-specific T cells, pharmaceutical compositions and kits for cell-based cancer immunotherapy.

Methods of cancer treatment using tumor antigen-specific T cells

A photography lamp includes a housing assembly, a heat dissipation assembly, and a light source assembly. The housing assembly includes a lamp barrel and a rear cover, a main air inlet is disposed on the rear cover, and an air outlet grille is disposed on a side wall of the lamp barrel close to the light outlet end. The heat dissipation assembly includes a fan, the air outlet side of the fan is spaced from the light source assembly, a spacing is arranged between the air outlet side of the fan and the light source assembly, and the spacing is always facing the air outlet grille in the direction of the central axis of the lamp barrel. The photography lamp can improve heat dissipation efficiency of photographic lighting fixtures.

Photography lamp

The present application relates to the technical field of films and television lighting, and provides a lamp and an optical lens thereof, the lamp includes: a lamp body, a first housing and a second housing, the first housing is provided with slots, the second housing is movably sleeved inside the first housing, and an outer wall of the second housing is provided with a protruding member extending through the slots, the protruding member further simultaneously moves relative to the second housing while moves in the slot, to adjust a distance between the second housing and the lamp body. When the protruding member moves in the slot on the first housing, a part of the protruding member can also move relative to the second housing at the same time.

Lamp and optical lens thereof

The present application discloses a microphone, including: a housing; at least two sound-pickup members respectively disposed on the housing; a control circuit board disposed in the housing and in electrical connection to the at least two sound-pickup members respectively; and a switch member configured for triggering the control circuit board to select one or more of the sound-pickup members for collecting an external sound source. The present application addresses the shortcoming that it is necessary to change the direction of the microphone according to the needs of the scene, realizes the flexible selection and configuration of multiple sound-pickup members, and enriches the use scene of the operator. Once the recording site is set up, recordings with different requirements can be realized by switching circuit, so as to reduce the movement of recording equipment, which is suitable for recording equipment such as a camera and a camcorder.

Growing community of inventors

Shenzhen, China

Xiangjun Zhou