Medtronic, Inc.

Tyrx, Inc.

University of Massachusetts

Xiangji Chen

Ronald A Drake

Jing Chen

Satish K Pulapura

Fatima Buevich

Suping Lyu

Darrel F Untereker

Kimberly A Chaffin

Matthew Jolly

Todd Emrick

Julie A Alkatout

Haining Na

Peter L Thor

Zhaoxu Wang

Dan Thanh Le

Thomas P Grailer

Jin Zhu

Adam J Buckalew

Samantha Page

Patricia E Dunn

Samuel E Owings

Samantha McRae

Samuel I Owings

A modified polyisobutylene-based polymer, method of making, and a medical device that includes such polymer, wherein the modified polyisobutylene-based polymer includes urethane, urea, or urethane-urea groups, hard segments, and soft segments, wherein the soft segments comprise phenoxy-containing polyisobutylene residues, and the hard segments include diisocyanate residues and optionally chain extender residues.

Modified polyisobutylene-based polymers, methods of making, and medical devices

A method for preparing tyrosine derived polyarylates includes combining a desaminotyrosyl-tyrosine ethyl ester, a desaminotyrosyl-tyrosine benzylester, succinic acid and a catalyst in a flask to produce a first mixture. Methylene chloride is added to the first mixture to produce a first suspension. Diisopropylcarbodiimide (DIPC) is added to the first mixture to produce a first solution. The first solution is added to a non-solvent to produce a precipitate. The precipitate is dissolved in methylene chloride to form a polymer solution. The polymer solution is blended with a slurry to produce polymer shreds. The polymer shreds are blended with a second slurry to produce a tyrosine derived polyarylate.

Synthesis of tyrosine derived polyarylates

A kit includes a mesh substrate and a polymer that is fixed to the mesh substrate. The polymer includes an active agent that is configured to elute over time. The kit further includes a hemostatic agent. The hemostatic agent is separate from the mesh substrate and the polymer. Systems and methods are disclosed.

Kits for local delivery of water soluble agents and methods of use

A method for hydrogenating tyrosine derived polyarylates includes dissolving a second polyarylate with DMF in a flask to produce a first solution. A catalyst is added to the first solution to produce a polymer solution. The polymer solution is filtered through a Celite bed to produce a filtrate. The filtrate is added to water and stirred to precipitate the polyarylate.

Hydrogenation of tyrosine derived polyarylates

The invention generally relates to zwitterionic polymers (including zwitterionic copolymers), such as polymethacrylic structures, with pendent functional moieties, such as therapeutic or biologic moieties. More particularly, the invention relates to phosphorylcholine-substituted methacrylic polymers prepared by free radical polymerization and click chemistry, for example, and compositions and products comprising same, as well as related methods and uses of the compositions, for example, as biological or therapeutic agents and in drug delivery thereof.

Zwitterionic polymers with therapeutic moieties

A composition, article, and method for increasing the hydrolytic stability of a polymer; wherein a composition includes: a polymer comprising functional groups having hydrolyzable bonds; a carbodiimide compound; and a weak base (or hindered amine); wherein the carbodiimide compound and weak base (or hindered amine) are used in amounts effective to decrease the rate and/or extent of hydrolytic degradation of the polymer relative to either used alone in the same amount with the polymer.

Hydrolytically stable polymer compositions, articles, and methods

A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution. EDCI HCl is added to the first solution to produce a first mixture. Ethyl acetate is added to the first mixture to produce a second mixture. The second mixture is added to sodium chloride to produce a third mixture having layer separation. An aqueous layer is removed from the third mixture. The third mixture is extracted with reagents after the aqueous layer has been removed from the third mixture to produce a fourth mixture. Magnesium sulfate is added to the fourth mixture to produce a fifth mixture. The fifth mixture is filtered to produce filtrate. The filtrate is concentrated. Crystallization of the concentrated filtrate is induced. Methylene chloride is added to the crystallized filtrate to produce a solid product.

Synthesis of tyrosine derived diphenol monomers

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Plymouth, MN, United States of America

Xiangji Chen