University of Texas System

Huahui Health Ltd.

Xiangbing Qi

Lei Zhang

Yang Liu

Zhiqiang Wang

Bo Peng

Huan Yan

Wenhui Li

Uttam K Tambar

Cheng-Yang Wu

Jacinta L Chuang

David T Chuang

R Max Wynn

Shih-Chia Tso

Wen-Jun Gui

The invention provides for treating HBV or HDV infection or inhibiting human sodium taurocholate co-transporting polypeptide (hNTCP) with a polymeric bile acid or salt thereof, and pharmaceutical compositions comprising a polymeric bile acid or salt thereof, and a second HBV or HDV medicament.

Polymeric bile acid derivatives inhibit Hepatitis B and D virus and NTCP transport

The present disclosure relates to the identification of PDK inhibitors and their use in the treatment of diseases such as diabetes, cardiovascular disease and cancer. The invention relates to the development of robust PDK inhibitors that can be used to improve glucose metabolism and correct metabolic dysfunction in vivo. Based on the unique structural features present in the ATP-binding pocket of PDK2, a single functional-group change was made in a known Hsp90 inhibitor that binds to the corresponding pocket of the latter protein from the GHKL family. This approach efficiently converted the Hsp90 inhibitor to a highly specific inhibitor for all PDK isoforms. These final PDK inhibitors of this series robustly augments PDC activity with reduced phosphorylation in tissues.

Inhibitors of mitochondrial pyruvate dehydrogenase kinase isoforms 1-4 and uses thereof

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Beijing, China

Xiangbing Qi