Peking University

Chinese Academy of Medical Sciences

Xiangbao Meng

Zhongjun Li

Yu Chen

Shan Liu

Xiaobo Sun

Siwang Yu

Meiqi Zhang

Guibo Sun

Huibo Xu

Dongbo Lu

Linling Que

An application of a combination or composition ofetand aspirin in the preparation of a drug for preventing and treating cardiovascular and cerebrovascular diseases, the combination or composition being as follows: the dose range ofetis 25-500 mg/d, and the dose range of aspirin is 20-700 mg/d. Theetcomprises commercially available products,et, an extract prepared fromet, an active ingredient ofetand a preparation ofet, and so on.etand aspirin have a synergistic effect, while reducing gastric mucosal damage caused by aspirin.

Use of combination or composition of Radix et Rhizoma Notoginseng and aspirin

This invention discloses the use of aza-tryptanthrin derivatives as an IDO1 and/or TDO inhibitors, and the derivatives are represented by the general Formula (I). The compounds represented by the Formula (I) have inhibitory effects on indoleamine-2,3-dioxygenase 1 (IDO1) and/or tryptophan-2,3-dioxygenase (TDO), and can be used for treating diseases having the pathological features of IDO1 and/or TDO-mediated tryptophan metabolism, including but not limited to tumors, autoimmune disease, infectious diseases, Alzheimer's disease, depression, anxiety. 

Use of aza-tryptanthrin derivatives as inhibitors of IDO1 and/or TDO

Provided is a fused acridine derivative as formula (I), which has good antitumor activity. In addition, also provided are a process for preparing the derivative, a pharmaceutical composition containing the derivative, and the use thereof. 

Fused acridine derivative and pharmaceutical composition, preparation method and use thereof

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