Isp Investments Inc.

Ironwood Pharmaceuticals, Inc.

Epix Pharmaceuticals, Inc.

Convatec Technologies, Inc.

Cyclerion Therapeutics, Inc.

Acurx Pharmaceuticals, LLC

Activbiotics Pharma, LLC

Eutropics Pharmaceuticals, Inc.

Activbiotics, Inc.

Amgen Inc.

University of Southern California

Rochal Industries Llp

Galenea Corp.

Xiang Y Yu

Timothy Claude Barden

Ara Mermerian

Colleen Hudson

Mark G Currie

Paul A Renhowe

David F Lewis

Glen Robert Rennie

Joel D Moore

James Edward Sheppeck

Rajesh R Iyengar

Joon Jung

Takashi Nakai

Thomas Wai-Ho Lee

Nicholas Robert Perl

G-Yoon Jamie Im

Karthik Iyer

Kimberly Kafadar Long

George Todd Milne

John Henry Van Duzer

James Michael Siedlecki

James Jia

Joseph C Salamone

Oren Becker

Ashis K Saha

Ann Beal Salamone

Srinivasa Rao Cheruku

Yael Marantz

William Bert Geiss

Douglas Gregory Stafford

Arthur F Michaelis

Mercedes Lobera

Yingfei Yang

Sharon Shacham

Jian Lin

Casey Cameron McComas

Minghua Wang

Li Huang Xing

Richard Soll

Silvia Noiman

Anurag Sharadendu

Mahesh Sambasivam

Michael Silverman

Pini Orbach

Nili Schutz

Hsiao-Yi Shih

Dilara McCauley

Victor J Cee

Brian Alan Lanman

Roland W Burli

Andrew Kolodziej

Lei Jia

Michael H Cardone

Susana C Neira

Joseph Raker

Carl A Listl

Kimberley Gannon

Robert Christian Penland

Andre Micke

Mark Edward Thompson

Angelika Fretzen

Kevin Sprott

Jennifer Elizabeth Golden

Dale S Dhanoa

Fikret Nuri Kirkbir

Zhaoda Zhang

Hanoch Senderowitz

Levi J Irwin

Laurence Wu

Jane Yang

Merav Fichman

Laurence I Wu

Rosa Melendez

Bo Peng

Dilârâ McCauley

Janette Anyumba

David Lewis Fairhurst

Changhong Zhang

Manuel Martin Orosco

Roland Burli

Guojin Lu

Paul Allen Renhowe

Rosa E Melendez

Mark Currie

Andrew F Kolodziej

Susana Neira

Robert C Penland

A silicone pressure sensitive adhesive with amphiphilic copolymers for maintaining adhesion in a moist environment. The amphiphilic copolymers for silicone adhesives include at least one silicone moiety and at least one hydrophilic segment. Such adhesives are applicable to securing medical devices to human skin.

Pressure sensitive adhesives with amphiphilic copolymer

Compounds of Formulae I' and I are described, which are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds are also useful for treating, preventing or managing various disorders that are herein disclosed. 

sGC stimulators

The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacterial infections. 

DNA polymerase IIIC inhibitors and use thereof

The present invention relates to compounds and methods useful for inhibiting the DNA polymerase IIIC enzyme. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of Gram-positive bacteria infections. 

Pressure sensitive adhesives with amphiphilic copolymers

A process for improving sensitivity of a film base, coated with a dispersion of a normally crystalline polyacetylenic compound in a non-solvating liquid which is dried on the film surface, to particular photon energy band, specifically, long wavelength UV; the polyacetylenic compound preferably having at least two conjugated acetylenic linkages and containing from 12 to 60 carbon atoms. The sensitization of the film to long wavelength UV is achieved via the addition of photoinitiator(s) capable of absorbing UV energy and converting it to free radicals.

Diacetylene film sensitized with photoinitiator and applications of the film

The present disclosure relates to compounds useful as inhibitors of the enzyme Fatty Acid Amide Hydrolase (FAAH). The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment or prevention of various disorders. Compounds of the invention are described in Table 1.

FAAH inhibitors

The invention relates to a chemotherapeutic cancer treatment in which compounds (BH3Is) are administered to a mammal to treat B-cell Lymphoma or other hematopoietic cancers, including diseases associated with MCL-1. The invention also provides a method for treating types of hematopoietic cancers, such as B-cell lymphoma, using a combination of one or more disclosed compounds in combination with other therapes, for example, 26S proteasome inhibitors, such as, for example, Bortezomib. The invention also relates to autoimmune treatment with pharmaceutical compositions comprising one or more disclosed compounds. The invention also relates to methods for identifying compounds, for example, compounds of the BH3 mimic class, that have unique in vitro properties that predict in vivo efficacy against B-cell lymphoma tumors and other cancers as well as autoimmune disease. Illustrative compounds are those of Formula II: 

Substituted 2,2'-biphenazines for treating diseases

The present invention relates to amphiphilic pressure sensitive adhesives, specifically, pressure sensitive adhesives with amphiphilic copolymers which improve adhesion under moist environment. The amphiphilic copolymers comprise at least one hydrophobic acrylic monomer or oligomer and at least one hydrophilic or amphiphilic monomer or oligomer. The present invention also relates to the use of such adhesives in securing medical devices to human skin.

Amphiphilic pressure sensitive adhesives for human skin adhesion

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Acton, MA, United States of America

Xiang Y Yu