Kohler Company

Chongqing Pharmaceutical Research Institute Co., Ltd

Yaopharma Co., Ltd.

Xiang Li

Xiaoqing Bai

Qiang Liu

Haoying Xu

Hongyi Liu

Hongkun Qin

Xiaolong Kerri Yan

Zhichao Xu

Youzhi Xiao

Wei Nie

Yaming Cao

The present disclosure relates to a GLP-1R agonist compound and use thereof, and specifically provides a compound represented by Formula I, or an isotope-labelled compound, a stereoisomer, or a pharmaceutically acceptable salt thereof, and use thereof as a medicament. The compound exhibits excellent agonistic effects and pharmacodynamic properties on GLP-1R and, as a modulator, is useful for manufacturing a medicament for the treatment, amelioration, or prevention of metabolic diseases and related diseases, thus having broad application prospects.

GLP-1R agonist compound and use thereof

A throttle assembly for an engine includes a remote control throttle lever, a manual throttle control lever, and a throttle return spring. The remote control throttle lever is configured to operate the throttle assembly and the engine based on a force received from an external device. The manual throttle control lever is configured to operate the throttle assembly and the engine based on a force received from a user input at an input portion of the manual throttle control lever. An abutment portion of the manual throttle control lever is spaced from the input portion of the manual throttle control lever and configured to abut the remote control throttle lever. The throttle return spring is configured to bias the remote control throttle lever against the abutment portion of the manual throttle control lever in an opposite direction of the force received from the external device.

Engine with remote throttle control and manual throttle control

Growing community of inventors

Chongqing, China

Xiang Li