Bristol-myers Squibb Compnay

Xiang Jun J Jiang

John E Macor

Gene Michael Dubowchik

Prasad V Chaturvedula

Graham S Poindexter

Guanglin Luo

George O Tora

Andrew P Degnan

Ling Chen

Xiaojun Han

Rita Civiello

George N Karageorge

Shikha Vig

The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors ('CGRP-receptor'), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

Anti-migraine spirocycles

Spirocyclic anti-migraine compounds

The present invention relates to methods of treating neurogenic vasodilation, neurogenic inflammaton, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors using pharmaceutical compositions comprising compounds of Formula (I) 

Anti-migraine treatments

Calcitonin gene related peptide receptor antagonists

Growing community of inventors

North Haven, CT, United States of America

Xiang Jun J Jiang