Chinese Academy of Sciences

Fukang (shanghai) Health Technology Co., Ltd.

Shanghai Acebright Pharmaceuticals Co., Ltd.

Fukang Health Technology Co., Ltd.

Xiajuan Huan

Jian Ding

Zehong Miao

Yi Chen

Ao Zhang

Zilan Song

Chunhao Yang

Cun Tan

Shanshan Song

Pingyuan Wang

Zhoulong Fan

Na Ye

Chuanhuizi Chen

Disclosed are a 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride polymorph, a preparation method therefor and an application thereof. Specifically, disclosed are three crystalline forms, i.e., crystalline forms A, B, and C, of 2-[4-(methylaminomethyl)phenyl]-5-fluoro-benzofuran-7-carboxamide hydrochloride (formula I), preparation methods for the three crystalline forms, and use of the three crystalline forms in preparation of drugs. 

2-[4-(meihylaminomethyl)phenyl]-5-fluoro- benzofuran-7-carboxamide hydrochloride polymorph, preparation method therefor and application thereof

A class of substituted triazolopiperazine compounds represented by formula (I), tautomers, enantiomers, diastereomers, racemates, metabolites, metabolic precursors, and pharmaceutically acceptable salts, esters, prodrugs or hydrate thereof, a preparation methods therefor, intermediates and a use thereof in the preparation of drugs for prevention and treatment of diseases associated with PARP including various ischemic diseases, neurodegenerative diseases and cancers. 

Substituted triazolopiperazine PARP inhibitor, preparation method therefor and use thereof

Provided is a piperazinotriazole compound represented by general formula I or a pharmaceutically acceptable salt, stereoisomer, tautomer or hydrate thereof. Also provided are a pharmaceutical composition comprising the compound, a method for preparing the compound and a method of use thereof as a high-selectivity poly(adenosine diphosphate-ribose)polymerase-1 (PARP-1) inhibitor in the preparation of drugs for the prevention and/or treatment of PARP-related diseases. 

Substituted [1,2,4]triazolo[4,3-a]pyrazines as PARP-1 inhibitors

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Xiajuan Huan