China Building Materials Academy

Beijing Baheal Chengchuang Pharmaceutical Research and Development Co., Ltd.

China Petroleum Chemical Corporation

Xia Zhao

Wei Li

Jie Zhang

Ling Wang

Song Song

Zhuo Zhang

Ying Zhou

Xue Wang

Aimin Liang

Xu He

Shichao Wang

Chuanqing Li

Guozhu Yu

Ran Xie

Bing Yan

Wenjuan Sun

Huiling Liu

Junling Zhang

Zhendi Wang

Xiaocong Pang

Yanlun Gu

Zhenming Liu

Yimin Cui

Qian Xiang

Xiaojiao Sun

Guixi Luan

Weipin Zhou

An indazole hydrazide compound, as represented in formula (I); wherein, R is selected from substituted alkyl, substituted alkenyl and substituted phenyl; substituent in the substituted alkyl and substituted alkenyl includes phenyl and/or substituted phenyl; R′ is selected from H and alkyl. Compared with the prior art, the above indole hydrazide compound can be used as integrin avβ3 receptor antagonist. Besides, it has obvious anti-prostate cancer activity and has a significant inhibitory effect on enzalutamide-resistant cell lines. In addition, the above-mentioned compound has obvious anti-tumor angiogenesis activity and can be used in the preparation of anti-tumor angiogenesis drugs to inhibit tumor angiogenesis.

Indazole hydrazide compound and application thereof

Provided is an apparatus for preparing a building structure with 3D printing, comprising: a 3D printing device (), having a storage chamber () and a printing head () connected to the storage chamber () and being movable relative to a base frame; and a reinforcing device, movably disposed relative to the base frame, and having a driving mechanism () for driving short rebars or short ribs to perform an insertion movement in a direction intersected with a stacking direction of a cement-based slurry layer; the driving mechanism inserts the short rebars or the short ribs into an interlayer interface spanning at least two adjacent cement-based slurry layers printed by the 3D printing device (). Also provided a method for preparing a building structure with 3D printing. There is no printing gap between the cement-based slurry layer printed by the apparatus and the inserted rebars, ensuring a tight connection between the cement slurry and the rebars, so that the mechanical properties and toughness of the interlayer interface between the cement-based materials of the 3D printing are truly improved.

Apparatus and method for preparing a building structure with 3D printing

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Beijing, China

Xia Zhao