The Brigham and Women's Hospital, Inc.

Harvard College

Xi Zhu

Omid C Farokhzad

Jinjun Shi

Ulrich Von Andrian

Jun Wu

Aude Thiriot

Xiaoding Xu

Yanlan Liu

This disclosure relates to nanoparticles comprising a core comprising a poly(ester amide) polymer comprising a repeating unit of Formula (Ia):  and a repeating unit of Formula (Ib):  wherein W, W, X, A, X, A, and Xare as described herein, a payload molecule within the core, and a surface layer comprising a targeting ligand that binds or reacts selectively with a receptor on the outside surface of a cell. Methods of making such nanoparticles, and methods of using such nanoparticles as drug delivery vehicles, are also provided.

Nanoparticles having poly(ester amide) polymer cores as drug delivery vehicles

This invention relates to amphiphile-polymer particles comprising obtaining a first solution comprising a water-insoluble polymer, a payload and a first amphiphile in a water-miscible solvent; mixing the first solution with an aqueous second solution to form an aqueous composition comprising a particle comprising a water-insoluble polymeric core comprising the water-insoluble polymer; the payload; and the first amphiphile.

Amphiphile-polymer particles

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Qingdao, China

Xi Zhu