Hewlett-packard Development Company, L.p.

Arena Pharmaceuticals, Inc.

Intevac, Inc.

Eotech, Inc.

Xi Zeng

Thuy-Anh Tran

Brett Ullman

Young-Jun Shin

Ning Zou

Jason Swei

Jason B Ibarra

Tao Chen

Eric Lee Burch

Christopher Arend Toles

Kali M Campbell

Xiaoqi Zhou

Bor-Jiunn Niu

Kenneth A Costello

Lokendra Pal

Kelly Ronk

Verle W Aebi

Sandeep K Bangaru

Yongzhong Wang

Haigang Chen

Molly L Hladik

Lisa A Underwood

Rajasekar Vaidyanathan

Verle Aebi

Michael Jurkovic

Christopher Toles

Pyrazole derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; Crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (SLE); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (COPD). 

Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto

A novel photocathode employing a conduction band barrier is described. Incorporation of a barrier optimizes a trade-off between photoelectron transport efficiency and photoelectron escape probability. The barrier energy is designed to achieve a net increase in photocathode sensitivity over a specific operational temperature range.

Thermally assisted negative electron affinity photocathode

A post-printing treatment for printed media includes a wax suspended in water. Particles of the wax to lie upon at least an inkjet ink image on the printed media to facilitate abrasion resistance of the image.

Post-printing treatment

A recording medium includes a protective layer and a porous ink receiving layer. The protective layer includes a first binder and a first set of polymeric beads. The first set of polymeric beads has an average volume-based particle size equal to or greater than ten microns. The protective layer has a coat weight equal to or less than three grams per square meter. The recording medium also includes a porous ink receiving layer including a first set of pigments and a second binder.

Recording medium having a protective layer

A coated medium for inkjet printing is disclosed. The coated medium includes a coating layer formed on at least one side of a supporting substrate. The coating layer includes precipitated calcium carbonate with an average particle size of less than about 1 micron, silica with a surface area of greater than 100 m/g, a third inorganic pigment with an average particle size greater than that of precipitated calcium carbonate and selected from the group consisting of ground calcium carbonate (GCC) and clays, and at least one binder, wherein silica is present in an amount of at least 15 parts based on 100 parts of inorganic pigments in total.

Coated medium for inkjet printing and method of fabricating the same

The present disclosure provides pre-treatment compositions and related methods. As such, a pre-treatment coating for a print medium can include a an evaporable solvent, a matrix, and a wax. The matrix can include from 5 wt % to 20 wt % of a fixer, from 5 wt % to 20 wt % of a low Tg latex, and from 30 wt % to 80 wt % of a high Tg latex. The wax can include from 5 wt % to 30 wt % of a wax. The weight percentages of the matrix and the wax are based on a total amount present in the pre-treatment coating after removal of solvent.

Pre-treatment coating

A recording medium includes a base substrate, a fusible layer including a first set of polymeric beads and a second set of polymeric beads, and an ink receiving layer disposed between the base substrate and the fusible layer. The first set of polymeric beads has an average volume-based particle size less than two microns. The second set of polymeric beads has an average volume-based particle size equal to or greater than five microns. The fusible layer includes a weight percent of the second set of polymeric beads of at least three percent.

Recording medium having first set and second set of polymeric beads

An inkjet recording material which comprises an extruded mixture of thermoplastic polymers and non-chlorinated polyolefin materials. The mixture contains from 0.5 wt % to 30 wt % of non-chlorinated polyolefin materials based on the total weight of the polymers constituting the material.

Inkjet recording material

A media suitable for inkjet web press printing is disclosed herein. The media includes a paper substrate and an ink receptive layer coated onto at least one surface of the paper substrate. The ink receptive layer includes: inorganic pigments; at least one water-based binder; a water-soluble metallic salt; a colorant durability enhancer selected from the group consisting of boric acid, borax, sodium tetraborate, phenyl boronic acid, butyl boronic acid and combinations thereof; and a coefficient of friction (COF) reducer selected from the group consisting of polyethylene wax, paraffin wax, carnauba wax, polypropylene wax, polytetrafluoroethylene wax, and combinations thereof.

Media for inkjet web press printing

A coated medium for inkjet printing, which includes a supporting substrate and a coating layer formed on at least one side thereof. The coating layer includes at least one binder and at least two different inorganic pigments: modified calcium carbonate (MCC) and either precipitated calcium carbonate (PCC) or clay.

Coated medium for inkjet printing

An inkjet recording material which comprises a supporting substrate, a first bottom base coat applied to at least one surface of said substrate, and a second topcoat layer applied over said base coat. In said inkjet recording material, the base coat includes a combination of at least three pigments and the topcoat layer comprises pigments selected from the group consisting of fumed silica, silica gel, precipitated silica, colloidal silica, fumed alumina, boehmite, pseudo-boehmite or a mixture thereof.

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San Diego, CA, United States of America

Xi Zeng