Institut Curie

Centre National De La Recherche Scientifique

Institut Pasteur

Ecole Nationale Veterinaire D'alfort

Institut National De La Recherche Agronomique

Institut National De La Recherche Agronomique (inra)

Xavier Sastre-Garau

Jean-Jacques Panthier

Florence Bernex

Giorgia Egidy

Sylvie Robine

François Amblard

Isabelle Cartier

The present invention concerns a method for diagnosing a melanoma in a mammal comprising the detection of the overexpression of RACK-1 protein in a melanocyte cell of said mammal, and the deduction of the presence of a melanoma from the overexpression of RACK-1 protein. The invention is also directed to a method for determining the tumoral status of a melanocyte cell of a mammal, comprising the detection of overexpression of RACK-1 protein in the melanocyte cell, and the deduction of the tumoral state of said cell from the overexpression of RACK-1 protein.

Upregulation of rack-1 in melanoma and its use as a marker

Upregulation of RACK-1 in melanoma and its use as a marker

The present invention concerns a method for diagnosing a melanoma in a mammal comprising the detection of the overexpression of RACK-1 protein in a melanocytic cell of said mammal, and the deduction of the presence of a melanoma from the overexpression of RACK-1 protein. The invention is also directed to a method for determining the tumoral status of a melanocytic cell of a mammal, comprising the detection of overexpression of RACK-1 protein in the melanocytic cell, and the deduction of the tumoral state of said cell from the overexpression of RACK-1 protein.

The present invention relates to methods and kits for predicting the outcome of cervical intra-epithelial neoplasia and methods for treating a cervical intra-epithelial neoplasia. More particularly, the methods comprise the determination of the presence of the HLA-DRB1*13 allele and the absence of a high risk human papillomavirus (HPV).

Methods and compositions for predicting the outcome of cervical intra-epithelial neoplasia

An installation is provided for multi-dimensional non-linear imaging of a material comprising intrinsic chromophores, using laser scanning. This installation comprises i) at least one source () of time stamp pulses of synchronized photons, ii) means () for locally focusing the pulses on a material to cause its intrinsic chromophores to absorb groups of at least two synchronized photons to produce response photons, iii) means () for directing the response photons to at leat one collecting zone, iv) means () for collecting the response photons in the collecting zone(s) whatever their energy, v) processing means for converting the collected photons into data at least representative of their number and storing them in correspondence with at least the time stamp pulses that cause the material to produce the response photons, vi) means for scanning () the pulses through a chosen area of the material, and vii) means for delivering from said data stored an image representative of said material chosen area, with a sub-millimeter resolution, and in function of the respective time stamp pulses of data.

Multi-photon imaging installation

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Vincennes, France

Xavier Sastre-Garau