Centre for Eye Research Australia Limited

Xavier Hadoux

Peter Van Wijngaarden

Francis Labrecque

Maxime Jannaud

Jonathan Guy Crowston

Flora Hui

Described herein is an ocular fundus imaging apparatus () including and an illumination module () and an imaging module (). The illumination module () includes light sources () configured to generate light at wavelengths within a desired spectral range. A first optical assembly is provided to shape and direct the light onto an eye () of a subject. A tuneable bandpass filter () selects a wavelength sub-interval within the desired spectral range. The imaging module () includes a second optical assembly to collect light returned from the eye () of the subject and to project the returned light from the eye () onto an image sensor (). The second optical assembly includes one or more optical elements capable of compensating for ocular variation. The image sensor () is configured to image the returned light to generate an image of the ocular fundus at the wavelength sub-interval.

Non-mydriatic hyperspectral ocular fundus camera

The present disclosure relates to a method and a system for quantifying a biomarker of a biological tissue. Two spectral sub-intervals are determined from a plurality of images of the tissue acquired at discrete wavelengths within a main wavelength interval using an imaging sensor in a manner such that the combination of the image data in the at least two spectral sub-intervals are correlated with a clinical variable of interest. The tissue is illuminated using one or more light sources with wavelengths within the at least two spectral sub-intervals. A measurement is of the light reflected by the tissue is acquired using an imaging sensor; and a measure of the biomarker of the tissue is calculated using the acquired measurement. The main wavelength interval is broader than each of the at least two spectral sub-intervals and at least one spectral confounder causing a spectral variability of the acquired image is present in the tissue.

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East Melbourne, Australia

Xavier Hadoux