Centre National De La Recherche Scientifique

UniversitÉ´de Rouen

Macquarie University

Institut De Recherche Pour Le Developpement

Institut National Des Sciences Appliquees De Rouen

Xavier Franck

Bruno Figadere

Alain Fournet

Fanny Schmidt

Reynald Hocquemiller

Pierre Champy

Philippe Peixoto

Peter Helmuth Karuso

Sylvia Rita Vozari

Mohamed Fakhfakh

Eric Prina

The present invention relates to a process for the total synthesis of epicocconone analogs of formula (I):  The invention also relates to novel epicocconone analogs.

Process for synthesizing epicconone analogs

The present invention relates to compounds of Formula (I) below, to their pharmaceutically acceptable salts and to their isomers or mixtures of isomers: HetAr&#x2014;X&#x2014;CHRR(I) in which: &#x2014;HetAr represents a group chosen from: &#x2014;X represents a linear, saturated or unsaturated, hydrocarbon-based chain comprising from 8 to 22 carbon atoms, optionally interrupted by an &#x2014;NH&#x2014; or &#x2014;NH&#x2014;CO&#x2014; group, &#x2014;Rrepresents a hydrogen atom or an &#x2014;OH, &#x2014;O(C-C)alkyl, &#x2014;OCO((C-C)alkyl), &#x2014;OSO((C-C)alkyl) or &#x2014;OSOH group, and &#x2014;Rrepresents a hydrogen atom or a (C-C)alkynyl, (C-C)alkenyl or (C-C)cycloalkyl group. The present invention also relates to a process for preparing the compounds of Formula (I), and also to the use thereof, especially in the treatment of neurodegenerative diseases. 

Quinoline or quinoxaline derivatives for treating neurodegenerative diseases

The invention relates to the use of quinolines having general formula (I), wherein Rdenotes H; alkyl C-C; alkenyl or alkynyl C-C; &#x2014;CHO; heteroaryl; alkyl C-Cor alkenyl or alkynyl C-Ccomprising at least one substituent selected from among O, halogen, &#x2014;OH, &#x2014;CHO, &#x2014;COOH, aryloxycarbonyl, alkyloxycarbonyl C-C, alkenyloxycarbonyl C-C, nitrile, aryl, heteroaryl, arylsulphone, alkylsulphone C-C, thioalkyl or aminoalkyl C-C; alkenyl C-Cbearing at least one substituent selected from among NH, aleoxy C-C, phenoxy, cycloakyl C-Cor heteroaryloxy, alkenyl or alkynyl C-Ccomprising at least one trialkylsilyl C-C; R, in position 3, 6 or 8, denotes H; halogen; &#x2014;OH; &#x2014;CHO; &#x2014;COOH; alkyl or aleoxy C-C; &#x2014;NH2; alkenyl C-C; or alkynyl C-C; Rand Rdo not both denote H. The invention is used for the preparation of a medicine to treat protozoan and retrovirus co-infections 

Substituted quinolines for the treatment of protozoa and retrovirus co-infections

Growing community of inventors

Bois Guillaume, France

Xavier Franck